LACTB
| Lactamase, beta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | LACTB ; G24; MRPL56 | ||||||||||||
| External IDs | OMIM: 608440 MGI: 1933395 HomoloGene: 12755 ChEMBL: 3791 GeneCards: LACTB Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 114294 | 80907 | |||||||||||
| Ensembl | ENSG00000103642 | ENSMUSG00000032370 | |||||||||||
| UniProt | P83111 | Q9EP89 | |||||||||||
| RefSeq (mRNA) | NM_001288585 | NM_030717 | |||||||||||
| RefSeq (protein) | NP_001275514 | NP_109642 | |||||||||||
| Location (UCSC) |
Chr 15: 63.12 – 63.14 Mb |
Chr 9: 66.96 – 66.98 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene.[1][2]
This gene encodes a 54 kDa protein sharing significant sequence similarity to serine proteases of the penicillin binding protein and beta-lactamase superfamily occurring in bacteria. [3] The amino acid residues necessary for serine protease activity in the bacterial penicillin binding proteins are conserved in LACTB indicating that LACTB has enzymatic activity although its enzymatic substrate remains unknown. LACTB is localized in the mitochondrial intermembrane space between the outer and inner mitochondrial membranes, and can polymerize into filaments that can be visualized by transmission electron microscopy. [4] Phylogenetic profiling shows that LACTB is associated with the mitochondrial respiratory complex I. [5] Gene network analyses demonstrate a causative link between LACTB and obesity. [6]
References
- ↑ Smith TS, Southan C, Ellington K, Campbell D, Tew DG, Debouck C (Nov 2001). "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain". Genomics 78 (1-2): 12–4. doi:10.1006/geno.2001.6643. PMID 11707067.
- ↑ "Entrez Gene: LACTB lactamase, beta".
- ↑ Peitsaro N, Polianskyte Z, Tuimala J, Pörn-Ares I, Liobikas J, Speer O, Lindholm D, Thompson J, Eriksson O (2008). "Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy". MBC Evolutionary Biology 8: 16. doi:10.1186/1471-2148-8-26. PMC 2266909. PMID 18226203.
- ↑ Polianskyte Z, Peitsaro N, Dapkunas A, Liobikas J, Soliymani R, Lalowski M, Speer O, Seitsonen J, Butcher S, Cereghetti GM, Linder MD, Merckel M, Thompson J, Eriksson O (2009). "LACTB is a filament-forming protein localized in mitochondria". Proceedings of the National Academy of Sciences USA 106 (45): 18960–18965. doi:10.1073/pnas.0906734106. PMC 2767363. PMID 19858488.
- ↑ Pagliarini D, Calvo S, Chang B, Sheth S, Vafai SB, Ong S, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK (2008). "A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology". Cell 134 (1): 112–123. doi:10.1016/j.cell.2008.06.016. PMC 2778844. PMID 18614015.
- ↑ Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNiel D, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy M-F, Zhang B, Emilsson V, Doss S, Shazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE (2008). "Variations in DNA elucidate molecular networks that cause disease". Nature 452 (March 27): 429–435. doi:10.1038/nature06757. PMC 2841398. PMID 18344982.
Further reading
- Hallis TM, Kopp AL, Gibson J, et al. (2007). "An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification.". Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 12 (5): 635–44. doi:10.1177/1087057107301499. PMID 17517902.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hell-Pourmojib M, Neuner P, Fischer H, et al. (2002). "Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.". J. Invest. Dermatol. 119 (1): 154–9. doi:10.1046/j.1523-1747.2002.01793.x. PMID 12164938.
- Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
This article is issued from Wikipedia - version of the Wednesday, January 27, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.