LBX1

Ladybird homeobox 1
Identifiers
Symbols	LBX1 ; HPX-6; HPX6; LBX1H; homeobox
External IDs	OMIM: 604255 MGI: 104867 HomoloGene: 4784 GeneCards: LBX1 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • heart looping • transcription, DNA-templated • muscle organ development • negative regulation of cell proliferation • anatomical structure morphogenesis • spinal cord motor neuron differentiation • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification • negative regulation of neuron differentiation • neuron fate determination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10660	16814
Ensembl	ENSG00000138136	ENSMUSG00000025216
UniProt	P52954	P52955
RefSeq (mRNA)	NM_006562	NM_010691
RefSeq (protein)	NP_006553	NP_034821
Location (UCSC)	Chr 10: 101.23 – 101.23 Mb	Chr 19: 45.23 – 45.24 Mb
PubMed search

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.^[1][2]

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.^[2]

References

1. Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev 53 (3): 345–56. doi:10.1016/0925-4773(95)00450-5. PMID 8645601.
2. "Entrez Gene: LBX1 ladybird homeobox 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.". Hum. Mol. Genet. 12 (16): 1959–71. doi:10.1093/hmg/ddg212. PMID 12913067.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm.". Genesis 29 (4): 172–9. doi:10.1002/gene.1021. PMID 11309850.
• Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells.". Gene 144 (2): 213–9. doi:10.1016/0378-1119(94)90380-8. PMID 7518789.