LHFP
| Lipoma HMGIC fusion partner | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | LHFP ; MGC22429 | ||||||||||
| External IDs | OMIM: 606710 MGI: 1920048 HomoloGene: 4223 GeneCards: LHFP Gene | ||||||||||
| EC number | 3.6.5.4 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 10186 | 108927 | |||||||||
| Ensembl | ENSG00000183722 | ENSMUSG00000048332 | |||||||||
| UniProt | Q9Y693 | Q8BM86 | |||||||||
| RefSeq (mRNA) | NM_005780 | NM_175386 | |||||||||
| RefSeq (protein) | NP_005771 | NP_780595 | |||||||||
| Location (UCSC) |
Chr 13: 39.34 – 39.6 Mb |
Chr 3: 53.04 – 53.26 Mb | |||||||||
| PubMed search | |||||||||||
Lipoma HMGIC fusion partner is a protein that in humans is encoded by the LHFP gene.[1][2]
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene (LHFPL1, LHFPL2) result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known.[2]
References
- ↑ Petit MM, Schoenmakers EF, Huysmans C, Geurts JM, Mandahl N, Van de Ven WJ (Aug 1999). "LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes". Genomics 57 (3): 438–41. doi:10.1006/geno.1999.5778. PMID 10329012.
- 1 2 "Entrez Gene: LHFP lipoma HMGIC fusion partner".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Longo-Guess CM, Gagnon LH, Cook SA, et al. (2005). "A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice". Proc. Natl. Acad. Sci. U.S.A. 102 (22): 7894–9. doi:10.1073/pnas.0500760102. PMC 1142366. PMID 15905332.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- LHFP human gene location in the UCSC Genome Browser.
- LHFP human gene details in the UCSC Genome Browser.
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