LHX6

LIM homeobox 6
Identifiers
Symbols	LHX6 ; LHX6.1
External IDs	OMIM: 608215 MGI: 1306803 HomoloGene: 7401 GeneCards: LHX6 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • zinc ion binding • sequence-specific DNA binding Cellular component • nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • cerebral cortex radially oriented cell migration • cerebral cortex tangential migration • cerebral cortex GABAergic interneuron migration • forebrain neuron fate commitment • cell maturation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26468	16874
Ensembl	ENSG00000106852	ENSMUSG00000026890
UniProt	Q9UPM6	Q9R1R0
RefSeq (mRNA)	NM_001242333	NM_001083125
RefSeq (protein)	NP_001229262	NP_001076594
Location (UCSC)	Chr 9: 122.2 – 122.23 Mb	Chr 2: 36.08 – 36.11 Mb
PubMed search

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.^[1][2]

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.^[2]

References

1. Kimura N, Ueno M, Nakashima K, Taga T (Oct 1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains". J Biochem 126 (1): 180–7. doi:10.1093/oxfordjournals.jbchem.a022420. PMID 10393337.
2. "Entrez Gene: LHX6 LIM homeobox 6".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Estécio MR, Youssef EM, Rahal P, et al. (2006). "LHX6 is a sensitive methylation marker in head and neck carcinomas.". Oncogene 25 (36): 5018–26. doi:10.1038/sj.onc.1209509. PMID 16732332.