LIMA1

LIM domain and actin binding 1

PDB rendering based on 2d8y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LIMA1 ; EPLIN; SREBP3
External IDs OMIM: 608364 MGI: 1920992 HomoloGene: 9484 GeneCards: LIMA1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51474 65970
Ensembl ENSG00000050405 ENSMUSG00000023022
UniProt Q9UHB6 Q9ERG0
RefSeq (mRNA) NM_001113546 NM_001113545
RefSeq (protein) NP_001107018 NP_001107017
Location (UCSC) Chr 12:
50.18 – 50.28 Mb
Chr 15:
99.78 – 99.88 Mb
PubMed search

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.[1][2][3][4]

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM][4]

References

  1. Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene 248 (1-2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID 10806352.
  2. Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene 18 (54): 7838–41. doi:10.1038/sj.onc.1203206. PMID 10618726.
  3. Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC 2172667. PMID 12566430.
  4. 1 2 "Entrez Gene: LIMA1 LIM domain and actin binding 1".

Further reading


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