LIMS1

LIM and senescent cell antigen-like domains 1

PDB rendering based on 1g47.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LIMS1 ; PINCH; PINCH-1; PINCH1
External IDs OMIM: 602567 HomoloGene: 68428 GeneCards: LIMS1 Gene
Orthologs
Species Human Mouse
Entrez 3987 110829
Ensembl ENSG00000169756 ENSMUSG00000019920
UniProt P48059 Q99JW4
RefSeq (mRNA) NM_001193482 NM_001193303
RefSeq (protein) NP_001180411 NP_001180232
Location (UCSC) Chr 2:
108.53 – 108.69 Mb
Chr 10:
58.32 – 58.42 Mb
PubMed search

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.[1][2][3]

Function

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.[3]

Interactions

LIMS1 has been shown to interact with Integrin-linked kinase[2][4] and NCK2.[2][5]

References

  1. Rearden A (Aug 1994). "A new LIM protein containing an autoepitope homologous to "senescent cell antigen"". Biochem. Biophys. Res. Commun. 201 (3): 1124–31. doi:10.1006/bbrc.1994.1822. PMID 7517666.
  2. 1 2 3 Tu Y, Li F, Goicoechea S, Wu C (Mar 1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Mol. Cell. Biol. 19 (3): 2425–34. doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.
  3. 1 2 "Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1".
  4. Zhang Y, Chen K, Guo L, Wu C (Oct 2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration". J. Biol. Chem. 277 (41): 38328–38. doi:10.1074/jbc.M205576200. PMID 12167643.
  5. Tu Y, Li F, Wu C (Dec 1998). "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways". Mol. Biol. Cell 9 (12): 3367–82. doi:10.1091/mbc.9.12.3367. PMC 25640. PMID 9843575.

Further reading


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