LIN9
| Lin-9 DREAM MuvB core complex component | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | LIN9 ; BARA; BARPsv; Lin-9; TGS; TGS1; TGS2 | ||||||||||||
| External IDs | OMIM: 609375 MGI: 1919818 HomoloGene: 35252 GeneCards: LIN9 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 286826 | 72568 | |||||||||||
| Ensembl | ENSG00000183814 | ENSMUSG00000058729 | |||||||||||
| UniProt | Q5TKA1 | Q8C735 | |||||||||||
| RefSeq (mRNA) | NM_001270409 | NM_001103182 | |||||||||||
| RefSeq (protein) | NP_001257338 | NP_001096652 | |||||||||||
| Location (UCSC) |
Chr 1: 226.23 – 226.31 Mb |
Chr 1: 180.64 – 180.69 Mb | |||||||||||
| PubMed search | |||||||||||||
Lin-9 homolog is a protein that is encoded by the LIN9 gene in humans.[1][2]
Interactions
LIN9 has been shown to interact with the retinoblastoma protein.[1]
References
- 1 2 Gagrica S, Hauser S, Kolfschoten I, Osterloh L, Agami R, Gaubatz S (Nov 2004). "Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein". The EMBO Journal 23 (23): 4627–38. doi:10.1038/sj.emboj.7600470. PMC 533054. PMID 15538385.
- ↑ "Entrez Gene: LIN9 lin-9 homolog (C. elegans)".
Further reading
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Korenjak M, Taylor-Harding B, Binné UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N, Brehm A (Oct 2004). "Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes". Cell 119 (2): 181–93. doi:10.1016/j.cell.2004.09.034. PMID 15479636.
- Sandoval R, Xue J, Tian X, Barrett K, Pilkinton M, Ucker DS, Raychaudhuri P, Kineman RD, Luque RM, Baida G, Zou X, Valli VE, Cook JL, Kiyokawa H, Colamonici OR (Aug 2006). "A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes". Experimental Cell Research 312 (13): 2465–75. doi:10.1016/j.yexcr.2006.04.002. PMID 16730350.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Pilkinton M, Sandoval R, Song J, Ness SA, Colamonici OR (Jan 2007). "Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1". The Journal of Biological Chemistry 282 (1): 168–75. doi:10.1074/jbc.M609924200. PMID 17098733.
- Osterloh L, von Eyss B, Schmit F, Rein L, Hübner D, Samans B, Hauser S, Gaubatz S (Jan 2007). "The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis". The EMBO Journal 26 (1): 144–57. doi:10.1038/sj.emboj.7601478. PMC 1782375. PMID 17159899.
- Pilkinton M, Sandoval R, Colamonici OR (Nov 2007). "Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex". Oncogene 26 (54): 7535–43. doi:10.1038/sj.onc.1210562. PMID 17563750.
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