LIPH
"LIPH" is also the ICAO code for Treviso Airport.
| Lipase, member H | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | LIPH ; AH; ARWH2; HYPT7; LAH2; LPDLR; PLA1B; mPA-PLA1 | ||||||||||||
| External IDs | OMIM: 607365 MGI: 2388029 HomoloGene: 71802 GeneCards: LIPH Gene | ||||||||||||
| EC number | 2.7.11.30 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 200879 | 239759 | |||||||||||
| Ensembl | ENSG00000163898 | ENSMUSG00000044626 | |||||||||||
| UniProt | Q8WWY8 | Q8CIV3 | |||||||||||
| RefSeq (mRNA) | NM_139248 | NM_001083894 | |||||||||||
| RefSeq (protein) | NP_640341 | NP_001077363 | |||||||||||
| Location (UCSC) |
Chr 3: 185.51 – 185.55 Mb |
Chr 16: 21.95 – 22 Mb | |||||||||||
| PubMed search | |||||||||||||
Lipase member H is an enzyme that in humans is encoded by the LIPH gene.[1][2][3]
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.[3]
References
- ↑ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
- ↑ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.
- 1 2 "Entrez Gene: LIPH lipase, member H".
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi:10.1093/hmg/ddg124. PMID 12719377.
- Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Aslam M, Chahrour MH, Razzaq A, et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMC 1735610. PMID 15520410.
- Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science 314 (5801): 982–5. doi:10.1126/science.1133276. PMID 17095700.
- Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281.
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