LMO1

LIM domain only 1 (rhombotin 1)
Identifiers
Symbols LMO1 ; RBTN1; RHOM1; TTG1
External IDs OMIM: 186921 MGI: 102812 HomoloGene: 48101 GeneCards: LMO1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4004 109594
Ensembl ENSG00000166407 ENSMUSG00000036111
UniProt P25800 Q924W9
RefSeq (mRNA) NM_001270428 NM_001302205
RefSeq (protein) NP_001257357 NP_001289134
Location (UCSC) Chr 11:
8.22 – 8.27 Mb
Chr 7:
109.14 – 109.17 Mb
PubMed search

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[1][2][3]

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[3]

Interactions

LMO1 has been shown to interact with GATA3[4][5] and TAL1.[6][7]

References

  1. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
  2. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood 77 (3): 599–606. PMID 1703797.
  3. 1 2 "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)".
  4. Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. (UNITED STATES) 18 (12): 6939–50. ISSN 0270-7306. PMC 109277. PMID 9819382.
  5. Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. (UNITED STATES) 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. ISSN 0021-9258. PMID 9020185.
  6. Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657. PMID 8078932.
  7. Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. (ENGLAND) 13 (20): 4831–9. ISSN 0261-4189. PMC 395422. PMID 7957052.

Further reading


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