LMO3

LIM domain only 3 (rhombotin-like 2)
Identifiers
Symbols LMO3 ; RBTN3; RBTNL2; RHOM3; Rhom-3
External IDs OMIM: 180386 MGI: 102810 HomoloGene: 136507 GeneCards: LMO3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 55885 109593
Ensembl ENSG00000048540 ENSMUSG00000030226
UniProt Q8TAP4 Q8BZL8
RefSeq (mRNA) NM_001001395 NM_207222
RefSeq (protein) NP_001001395 NP_997105
Location (UCSC) Chr 12:
16.55 – 16.61 Mb		 Chr 6:
138.36 – 138.58 Mb
PubMed search

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.[1][2][3] LMO3 interacts with the tumor suppressor p53 and regulates its function.[4] LMO3 is considered to be an oncogene in Neuroblastoma.[5]

References

  1. ↑ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  2. ↑ Shi, J; Cai, W; Chen, X; Ying, K; Zhang, K; Xie, Y (2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251.
  3. ↑ EntrezGene 55885
  4. ↑ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  5. ↑ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading

  • Friedel, S; Saar, K; Sauer, S; Dempfle, A; Walitza, S; Renner, T; Romanos, M; Freitag, C; et al. (2007). "Association and linkage of allelic variants of the dopamine transporter gene in ADHD". Molecular Psychiatry 12 (10): 923–33. doi:10.1038/sj.mp.4001986. PMID 17579611. 
  • Davis, Caroline; Levitan, Robert D; Kaplan, Allan S; Carter, Jacqueline; Reid, Caroline; Curtis, Claire; Patte, Karen; Kennedy, James L (2007). "Dopamine Transporter Gene (DAT1) Associated with Appetite Suppression to Methylphenidate in a Case–Control Study of Binge Eating Disorder". Neuropsychopharmacology 32 (10): 2199–206. doi:10.1038/sj.npp.1301348. PMID 17314918. 
  • Lim, Janghoo; Hao, Tong; Shaw, Chad; Patel, Akash J.; Szabó, Gábor; Rual, Jean-François; Fisk, C. Joseph; Li, Ning; et al. (2006). "A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Rual, Jean-François; Venkatesan, Kavitha; Hao, Tong; Hirozane-Kishikawa, Tomoko; Dricot, Amélie; Li, Ning; Berriz, Gabriel F.; Gibbons, Francis D.; et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Aoyama, M.; Ozaki, T; Inuzuka, H; Tomotsune, D; Hirato, J; Okamoto, Y; Tokita, H; Ohira, M; et al. (2005). "LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma". Cancer Research 65 (11): 4587–97. doi:10.1158/0008-5472.CAN-04-4630. PMID 15930276. 
  • Gerhard, DS; Wagner, L; Feingold, EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Ota, Toshio; Suzuki, Yutaka; Nishikawa, Tetsuo; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji; et al. (2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Mammalian Gene Collection Program Team* (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Foroni, L; Boehm, T; White, L; Forster, A; Sherrington, P; Liao, XB; Brannan, CI; Jenkins, NA; et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development*1". Journal of Molecular Biology 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID 1507224. 
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