LMO4

LIM domain only 4
PDB rendering based on 1rut.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L4Z​
Identifiers
Symbol	LMO4
External IDs	OMIM: 603129 MGI: 109360 HomoloGene: 4927 GeneCards: LMO4 Gene
Gene ontology Molecular function • enhancer sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • transcription factor binding • zinc ion binding Cellular component • transcription factor complex Biological process • neural tube closure • ventricular septum development • transcription from RNA polymerase II promoter • ventral spinal cord interneuron differentiation • spinal cord motor neuron differentiation • spinal cord association neuron differentiation • negative regulation of protein complex assembly • regulation of cell fate specification • positive regulation of transcription from RNA polymerase II promoter • thymus development • regulation of cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8543	16911
Ensembl	ENSG00000143013	ENSMUSG00000028266
UniProt	P61968	P61969
RefSeq (mRNA)	NM_006769	NM_001161769
RefSeq (protein)	NP_006760	NP_001155241
Location (UCSC)	Chr 1: 87.33 – 87.35 Mb	Chr 3: 144.19 – 144.21 Mb
PubMed search

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.^[1]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.^[1]

Interactions

LMO4 has been shown to interact with LDB1,^[2][3] RBBP8^[2][4] and BRCA1.^[2][4]

References

1. "Entrez Gene: LMO4 LIM domain only 4".
2. Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer (United States) 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972.
3. Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. (England) 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888.
4. Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. (United States) 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867.

Further reading

• Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. doi:10.1073/pnas.95.19.11257. PMC 21629. PMID 9736723.
• Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene.". Biochim. Biophys. Acta 1445 (1): 148–53. doi:10.1016/s0167-4781(99)00037-8. PMID 10209267.
• Tse E, Grutz G, Garner AA, et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.". Mamm. Genome 10 (11): 1089–94. doi:10.1007/s003359901167. PMID 10556429.
• Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
• Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.". J. Biomol. NMR 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID 12153047.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vu D, Marin P, Walzer C, et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells.". Brain Res. Mol. Brain Res. 115 (2): 93–103. doi:10.1016/S0169-328X(03)00119-0. PMID 12877980.
• Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
• Sutherland KD, Visvader JE, Choong DY, et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.". Int. J. Cancer 107 (1): 155–8. doi:10.1002/ijc.11343. PMID 12925972.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.". J. Biol. Chem. 280 (13): 12747–57. doi:10.1074/jbc.M500175200. PMID 15677447.
• Sun T, Patoine C, Abu-Khalil A, et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.". Science 308 (5729): 1794–8. doi:10.1126/science.1110324. PMC 2756725. PMID 15894532.
• Sum EY, Segara D, Duscio B, et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. doi:10.1073/pnas.0502990102. PMC 1140463. PMID 15897450.
• Jeffries CM, Graham SC, Stokes PH, et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization.". Protein Sci. 15 (11): 2612–8. doi:10.1110/ps.062377006. PMC 2242402. PMID 17001033.