LPCAT1

Lysophosphatidylcholine acyltransferase 1
Identifiers
Symbols	LPCAT1 ; AYTL2; PFAAP3; lpcat
External IDs	OMIM: 610472 HomoloGene: 9871 GeneCards: LPCAT1 Gene
EC number	2.3.1.23, 2.3.1.67
Gene ontology Molecular function • calcium ion binding • 1-alkenylglycerophosphocholine O-acyltransferase activity • 1-acylglycerophosphocholine O-acyltransferase activity • 1-acylglycerophosphocholine O-acyltransferase activity • 1-alkylglycerophosphocholine O-acyltransferase activity • 1-alkylglycerophosphocholine O-acetyltransferase activity Cellular component • Golgi membrane • endoplasmic reticulum • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • lipid particle • membrane • integral component of membrane Biological process • phospholipid metabolic process • phosphatidic acid biosynthetic process • phospholipid biosynthetic process • triglyceride biosynthetic process • phosphatidylglycerol acyl-chain remodeling • phosphatidylcholine acyl-chain remodeling • phosphatidylcholine acyl-chain remodeling • surfactant homeostasis • cellular lipid metabolic process • small molecule metabolic process • positive regulation of protein catabolic process • glycerophospholipid biosynthetic process • retina development in camera-type eye • negative regulation of phosphatidylcholine biosynthetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79888	210992
Ensembl	ENSG00000153395	ENSMUSG00000021608
UniProt	Q8NF37	Q3TFD2
RefSeq (mRNA)	NM_024830	NM_145376
RefSeq (protein)	NP_079106	NP_663351
Location (UCSC)	Chr 5: 1.46 – 1.52 Mb	Chr 13: 73.47 – 73.52 Mb
PubMed search

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.^[1]

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.^[2]

References

1. "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
2. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.