LRRN2
| Leucine rich repeat neuronal 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LRRN2 ; FIGLER7; GAC1; LRANK1; LRRN5 | ||||||||||||
| External IDs | OMIM: 605492 MGI: 106037 HomoloGene: 21274 GeneCards: LRRN2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10446 | 16980 | |||||||||||
| Ensembl | ENSG00000170382 | ENSMUSG00000026443 | |||||||||||
| UniProt | O75325 | Q6PHP6 | |||||||||||
| RefSeq (mRNA) | NM_006338 | NM_010732 | |||||||||||
| RefSeq (protein) | NP_006329 | NP_034862 | |||||||||||
| Location (UCSC) |
Chr 1: 204.62 – 204.69 Mb |
Chr 1: 132.88 – 132.94 Mb | |||||||||||
| PubMed search | |||||||||||||
Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.[1][2]
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[2]
References
- ↑ Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.
- 1 2 "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".
Further reading
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585.
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