LSP1

Lymphocyte-specific protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BH8​, 4NO0​, 4NO2​
Identifiers
Symbols	LSP1 ; WP34; pp52
External IDs	OMIM: 153432 MGI: 96832 HomoloGene: 1750 GeneCards: LSP1 Gene
Gene ontology Molecular function • actin binding • signal transducer activity Cellular component • plasma membrane • actin cytoskeleton • membrane • extracellular exosome Biological process • movement of cell or subcellular component • chemotaxis • cellular defense response • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4046	16985
Ensembl	ENSG00000130592	ENSMUSG00000018819
UniProt	P33241	P19973
RefSeq (mRNA)	NM_001013253	NM_001136071
RefSeq (protein)	NP_001013271	NP_001129543
Location (UCSC)	Chr 11: 1.85 – 1.89 Mb	Chr 7: 142.46 – 142.49 Mb
PubMed search

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.^[1][2]

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.^[2]

References

1. Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784.
2. "Entrez Gene: LSP1 lymphocyte-specific protein 1".

Further reading

• Jongstra-Bilen J, Young AJ, Chong R, Jongstra J (1990). "Human and mouse LSP1 genes code for highly conserved phosphoproteins". J. Immunol. 144 (3): 1104–10. PMID 2295815.
• Klein DP, Jongstra-Bilen J, Ogryzlo K, et al. (1989). "Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane". Mol. Cell. Biol. 9 (7): 3043–8. PMC 362773. PMID 2674678.
• Li Y, Guerrero A, Howard TH (1995). "The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines". J. Immunol. 155 (7): 3563–9. PMID 7561054.
• Misener VL, Hui C, Malapitan IA, et al. (1995). "Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells". J. Cell. Sci. 107 (12): 3591–600. PMID 7706408.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Howard T, Li Y, Torres M, et al. (1994). "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein". Blood 83 (1): 231–41. PMID 8274738.
• May W, Korenberg JR, Chen XN, et al. (1993). "Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family". Genomics 15 (3): 515–20. doi:10.1006/geno.1993.1102. PMID 8468046.
• Thompson AA, Omori SA, Gilly MJ, et al. (1997). "Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms". Genomics 32 (3): 352–7. doi:10.1006/geno.1996.0129. PMID 8838798.
• Huang CK, Zhan L, Ai Y, Jongstra J (1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils". J. Biol. Chem. 272 (1): 17–9. doi:10.1074/jbc.272.1.17. PMID 8995217.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Palker TJ, Fong AM, Scearce RM, et al. (1999). "Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation". Hybridoma 17 (6): 497–507. doi:10.1089/hyb.1998.17.497. PMID 9890705.
• Pulford K, Jones M, Banham AH, et al. (1999). "Lymphocyte-specific protein 1: a specific marker of human leucocytes". Immunology 96 (2): 262–71. doi:10.1046/j.1365-2567.1999.00677.x. PMC 2326732. PMID 10233704.
• Zhang Q, Li Y, Howard TH (2000). "Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains". J. Immunol. 165 (4): 2052–8. doi:10.4049/jimmunol.165.4.2052. PMID 10925289.
• Zhang Q, Li Y, Howard TH (2002). "Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains". Cell Motil. Cytoskeleton 49 (4): 179–88. doi:10.1002/cm.1031. PMID 11746662.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wong MJ, Malapitan IA, Sikorski BA, Jongstra J (2003). "A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids". Biochim. Biophys. Acta 1642 (1–2): 17–24. doi:10.1016/S0167-4889(03)00082-X. PMID 12972289.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell. Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs.00955. PMID 15090600.
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.