LSS
LSS may refer to:
- Lakeland School System, school district in Lakeland, Tennessee
- Langstaff Secondary School, Richmond Hill, Ontario
- Large-scale structure of the universe
- Laurel Springs School, Ojai, California, United States
- Lawrence Sheriff School, Rugby, Warwickshire
- Lean Six Sigma, a synergized managerial concept of Lean manufacturing and Six Sigma
- Leicester Secular Society, the world's oldest Secular Society
- Licentiate of Sacred Scripture, see Licentiate of Sacred Theology
- Life Saving Society
- Life Span Study of atomic bomb survivors, see Epidemiology data for low-linear energy transfer radiation
- Lithic Studies Society
- Lincoln Square Synagogue, Manhattan, New York City
- London School of Sound, school of music production based in London, United Kingdom
- Lone Star Showdown, the official rivalry between the Texas A&M Aggies and the Texas Longhorns
- Lone Star Steel Company, a tubular steel mill in Lone Star, Texas
- LSS (gene), an enzyme
- LSS Data Systems, a medical software company
- Lumbar spinal stenosis, a medical condition in which the spinal canal narrows
- Lunds Studentsångförening, a Swedish male-voice choir
- XM26 Lightweight Shotgun System
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