LTBP3

Latent transforming growth factor beta binding protein 3
Identifiers
Symbols	LTBP3 ; DASS; LTBP-3; LTBP2; STHAG6; pp6425
External IDs	OMIM: 602090 MGI: 1101355 HomoloGene: 7405 GeneCards: LTBP3 Gene
Gene ontology Molecular function • calcium ion binding • transforming growth factor beta binding Cellular component • extracellular region • extracellular matrix • extracellular exosome Biological process • extracellular matrix organization • transforming growth factor beta activation • positive regulation of mesenchymal stem cell proliferation • positive regulation of mesenchymal stem cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4054	16998
Ensembl	ENSG00000168056	ENSMUSG00000024940
UniProt	Q9NS15	Q61810
RefSeq (mRNA)	NM_001130144	NM_008520
RefSeq (protein)	NP_001123616	NP_032546
Location (UCSC)	Chr 11: 65.54 – 65.56 Mb	Chr 19: 5.74 – 5.76 Mb
PubMed search

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.^[1][2]

References

1. Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U (May 1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)". Mamm Genome 6 (1): 42–5. doi:10.1007/BF00350892. PMID 7719025.
2. "Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3".

Further reading

• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
• Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (Pt 3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
• Morén A, Olofsson A, Stenman G, et al. (1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J. Biol. Chem. 269 (51): 32469–78. PMID 7798248.
• Michel K, Roth S, Trautwein C, et al. (1998). "Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region". Hepatology 27 (6): 1592–9. doi:10.1002/hep.510270619. PMID 9620332.
• Saharinen J, Keski-Oja J (2000). "Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β". Mol. Biol. Cell 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
• Brooke JS, Cha JH, Eidels L (2002). "Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor". BMC Cell Biol. 3: 2. doi:10.1186/1471-2121-3-2. PMC 65547. PMID 11846885.
• Chen Y, Dabovic B, Annes JP, Rifkin DB (2002). "Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion". FEBS Lett. 517 (1–3): 277–80. doi:10.1016/S0014-5793(02)02648-0. PMID 12062452.
• Penttinen C, Saharinen J, Weikkolainen K, et al. (2003). "Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta". J. Cell. Sci. 115 (Pt 17): 3457–68. PMID 12154076.
• Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J (2005). "Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts". Exp. Cell Res. 310 (2): 370–82. doi:10.1016/j.yexcr.2005.08.008. PMID 16157329.
• Kantola AK, Keski-Oja J, Koli K (2006). "Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements". Gene 363: 142–50. doi:10.1016/j.gene.2005.07.042. PMID 16223572.