LY6E

Lymphocyte antigen 6 complex, locus E
Identifiers
Symbols	LY6E ; RIG-E; RIGE; SCA-2; SCA2; TSA-1
External IDs	OMIM: 601384 MGI: 106651 HomoloGene: 56411 GeneCards: LY6E Gene
Gene ontology Molecular function • GPI anchor binding Cellular component • integral component of plasma membrane • anchored component of membrane Biological process • in utero embryonic development • cell surface receptor signaling pathway • adrenal gland development • organ growth • norepinephrine metabolic process • epinephrine secretion • ventricular cardiac muscle tissue morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4061	17069
Ensembl	ENSG00000160932	ENSMUSG00000022587
UniProt	Q16553	Q64253
RefSeq (mRNA)	NM_001127213	NM_001164036
RefSeq (protein)	NP_001120685	NP_001157508
Location (UCSC)	Chr 8: 143.02 – 143.02 Mb	Chr 15: 74.96 – 74.96 Mb
PubMed search

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^[1][2][3] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. ^[4] Ly6E is associated with drug resistance and tumor immune escape in breast cancer. ^[5] Further research is required to validate Ly6E for translation research.

References

1. Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol 157 (3): 969–73. PMID 8757598.
2. Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC: 39161. PMID 8650192.
3. "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
4. Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMID 26862846.
5. Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-ß promotes breast cancer progression, immune escape and drug resistance". Cancer Research: canres.2654.2015. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB (1997). "A gain of novel tissue specificity in the human Ly-6 gene E48". J. Immunol. 159 (10): 4879–86. PMID 9366413.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG (1998). "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1". J. Immunol. 160 (1): 197–208. PMID 9551972.
• Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T (1998). "Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex". J. Biol. Chem. 273 (20): 12301–6. doi:10.1074/jbc.273.20.12301. PMID 9575182.
• Ding L, Shevach EM (2001). "Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen". Immunology 104 (1): 28–36. doi:10.1046/j.1365-2567.2001.01275.x. PMC: 1783287. PMID 11576217.
• Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ (2002). "Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland". Mol. Cell. Biol. 22 (3): 946–52. doi:10.1128/MCB.22.3.946-952.2002. PMC: 133557. PMID 11784869.
• de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH (2003). "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma". Int. J. Cancer 103 (6): 768–74. doi:10.1002/ijc.10903. PMID 12516096.