Lactocepin

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Lactocepin (EC 3.4.21.96, CEP, extracellular lactococcal proteinase, lactococcal cell wall-associated proteinase, lactococcal cell envelope-associated proteinase, lactococcal proteinase, PrtP) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Endopeptidase activity with very broad specificity, although some subsite preferences have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position [1,2]. Best known for its action on caseins, although it has been shown to hydrolyse hemoglobin and oxidized insulin B chain

This ezyme is associated with the cell envelope of Lactococcus lactis and attached via a C-terminal membrane anchor sequence.

References

↑ Visser, S., Robben, A.J.P.M. and Slangen, C.J. (1991). "Specificity of a cell-envelope-located proteinase (PIII-type) from Lactococcus lactis' subsp. cremoris AM1 in its action on bovine β-casein". Appl. Microbiol. Biotechnol. 35: 477–483. doi:10.1007/bf00169753. PMID 1367552.
↑ Monnet, V., Ley, J.P. and Gonzalez, S. (1992). "Substrate specificity of the cell envelope-located proteinase of Lactococcus lactis' subsp. lactis NCDO763". Int. J. Biochem. 24: 707–718. doi:10.1016/0020-711x(92)90004-k. PMID 1592148.
↑ Exterkate, F.A., Alting, A.C. and Bruinenberg, P.G. (1993). "Diversity of cell envelope proteinase specificity among strains of Lactococcus lactis' and its relationship to charge characteristics of the substrate-binding region". Appl. Environ. Microbiol. 59: 3640–3647. PMID 8285671.
↑ Pritchard, G.G. and Coolbear, T. (1993). "The physiology and biochemistry of the proteolytic system in lactic acid bacteria". FEMS Microbiol. Rev. 12: 179–206. doi:10.1111/j.1574-6976.1993.tb00018.x. PMID 8398214.

External links

Lactocepin at the US National Library of Medicine Medical Subject Headings (MeSH)

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic

Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator

Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase

Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin

Venombin	Ancrod Batroxobin

Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin Streptokinase S1P Cathepsin A G

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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