Leucine carboxyl methyltransferase 1

Leucine carboxyl methyltransferase 1
Rendering based on PDB 3IEI​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3IEI​, 3O7W​, 3P71​
Identifiers
Symbols	LCMT1 ; CGI-68; LCMT; PPMT1
External IDs	OMIM: 610286 MGI: 1353593 HomoloGene: 41123 GeneCards: LCMT1 Gene
EC number	2.1.1.233
Gene ontology Molecular function • protein C-terminal carboxyl O-methyltransferase activity • protein binding • S-adenosylmethionine-dependent methyltransferase activity Cellular component • cytosol Biological process • cellular protein modification process • protein methylation • C-terminal protein methylation • regulation of glucose metabolic process • negative regulation of protein complex assembly • regulation of apoptotic process • regulation of mitotic cell cycle spindle assembly checkpoint Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51451	30949
Ensembl	ENSG00000205629	ENSMUSG00000030763
UniProt	Q9UIC8	A2RTH5
RefSeq (mRNA)	NM_001032391	NM_025304
RefSeq (protein)	NP_001027563	NP_079580
Location (UCSC)	Chr 16: 25.11 – 25.18 Mb	Chr 7: 123.38 – 123.43 Mb
PubMed search

Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene.^[1][2]

Interactions

LCMT1 has been shown to interact with FXR2.^[3]

References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
2. "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Lee JA, Pallas DC (Oct 2007). "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells". The Journal of Biological Chemistry 282 (42): 30974–84. doi:10.1074/jbc.M704861200. PMC 3516869. PMID 17724024.
• De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.