Liarozole

Liarozole
Names

IUPAC name 6-[(3-Chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole
Identifiers
CAS Number	115575-11-6
ChemSpider	54664
IUPHAR/BPS	5210
Jmol interactive 3D	Image
PubChem	60652
InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYSA-N InChI=1/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYAV
SMILES C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4
Properties
Chemical formula	C₁₇H₁₃ClN₄
Molar mass	308.77 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Liarozole is a retinoic acid metabolism-inhibiting chemical.^[1]

Synthesis

Liarozole synthesis from Lednicer book 6 (Drugs of the Future citation).

References

↑ Vahlquist, A; Blockhuys, S; Steijlen, P; Van Rossem, K; Didona, B; Blanco, D; Traupe, H (2013). "Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial". The British journal of dermatology 170 (1): n/a. doi:10.1111/bjd.12626. PMID 24102348.

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