Linoleate 9S-lipoxygenase

Linoleate 9S-lipoxygenase (EC 1.13.11.58, 9-lipoxygenase, 9S-lipoxygenase, linoleate 9-lipoxygenase, LOX1 (gene), 9S-LOX) is an enzyme with systematic name linoleate:oxygen 9S-oxidoreductase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

linoleate + O₂

\rightleftharpoons

(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

Linoleate 9S-lipoxygenase contains nonheme iron.

References

↑ Vellosillo, T., Martinez, M., Lopez, M.A., Vicente, J., Cascon, T., Dolan, L., Hamberg, M. and Castresana, C. (2007). "Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade". Plant Cell 19 (3): 831–846. doi:10.1105/tpc.106.046052. PMC 1867370. PMID 17369372.
↑ Boeglin, W.E., Itoh, A., Zheng, Y., Coffa, G., Howe, G.A. and Brash, A.R. (2008). "Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases". Lipids 43 (11): 979–987. doi:10.1007/s11745-008-3230-1. PMID 18795358.
↑ Andreou, A.Z., Hornung, E., Kunze, S., Rosahl, S. and Feussner, I. (2009). "On the substrate binding of linoleate 9-lipoxygenases". Lipids 44 (3): 207–215. doi:10.1007/s11745-008-3264-4. PMID 19037675.
↑ Bannenberg, G., Martinez, M., Hamberg, M. and Castresana, C. (2009). "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana". Lipids 44 (2): 85–95. doi:10.1007/s11745-008-3245-7. PMID 18949503.

External links

Linoleate 9S-lipoxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: monooxygenases (EC 1.13)

1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase

1.13.12: one atom of oxygen	Firefly luciferase

1.13.99: other	Inositol oxygenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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