Linolenate 9R-lipoxygenase

Linolenate 9R-lipoxygenase (EC 1.13.11.61, NspLOX, (9R)-LOX, linoleate 9R-dioxygenase) is an enzyme with systematic name alpha-linolenate:oxygen (9R)-oxidoreductase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

alpha-linolenate + O₂

\rightleftharpoons

(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate

In cyanobacteria the enzyme is involved in oxylipin biosynthesis.

References

↑ Jerneren, F., Hoffmann, I. and Oliw, E.H. (2010). "Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus". Arch. Biochem. Biophys. 495 (1): 67–73. doi:10.1016/j.abb.2009.12.022. PMID 20043865.
↑ Andreou, A.Z., Vanko, M., Bezakova, L. and Feussner, I. (2008). "Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms". Phytochemistry 69 (9): 1832–1837. doi:10.1016/j.phytochem.2008.03.002. PMID 18439634.
↑ Lang, I., Gobel, C., Porzel, A., Heilmann, I. and Feussner, I. (2008). "A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120". Biochem. J. 410 (2): 347–357. doi:10.1042/BJ20071277. PMID 18031288.

External links

Linolenate 9R-lipoxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: monooxygenases (EC 1.13)

1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase

1.13.12: one atom of oxygen	Firefly luciferase

1.13.99: other	Inositol oxygenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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