List of adverse effects of risperidone

List of adverse effects of risperidone:

Sources:^[1][2][3]

Note: The percentages provided next to these adverse effects is the incidence of them according to DrugPoint.^[1]

Common (≥1%)

• Rash (oral, adults, 1% to 4%; pediatrics, up to 11% ; IM, less than 4%)
• Hyperprolactinaemia (risperidone is probably the most notorious antipsychotic for causing hyperprolactinaemia via its potent blockade of D2 receptors expressed on the lactotrophic cells of the pituitary)^[4] (oral, adults, less than 1%; pediatrics, 49% to 87% ; IM, less than 4%)
• Weight gain (causes less weight gain than clozapine, olanzapine and zotepine, around as much weight gain as quetiapine and more weight gain than amisulpride, aripiprazole, lurasidone, asenapine and ziprasidone)^[4] (oral, adult, 8.7% to 20.9%; pediatric, 14% to 32.6% ; IM, adult, 8% to 10%)
• Seborrhea
• Constipation (oral, 8% to 21% ; IM, 5% to 7%)
• Diarrhoea (oral, 1% to 8% ; IM, less than 4%)
• Excessive Salivation (oral, 1% to 10% ; IM, 1% to 4%)
• Increased appetite (oral, adult, more than 5%; pediatric, 4% to 47% ; IM, 4%)
• Indigestion (oral, 2% to 10% ; IM, 6%)
• Nausea (oral, 4% to 16% ; IM, 3% to 4%)
• Vomiting (oral, 10% to 25% ; IM, less than 4%)
• Upper abdominal pain (oral, adult, more than 5%; pediatric, 13% to 16%)
• Xerostomia (oral, 4% to 15% ; IM, up to 7%)
• Akathisia (oral, up to 10% ; IM, 4% to 11%)
• Dizziness (oral, 4% to 16% ; IM, 3% to 11%)
• Dyspnoea
• Asthenia
• Agitation
• Urinary incontinence
• Arthralgia
• Myalgia
• Epistaxis
• Somnolence (oral, adult, 3% to 6%; pediatric, 8% to 29% )
• Sleep disturbances
• Dose-dependent extrapyramidal side effects such as dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6% ; IM, adult, less than 4%), tremor (oral, 2% to 12% ; IM, 3% to 24%) and Parkinsonism (oral, 6% to 28% ; IM, 8% to 15%)
• Blurred vision (oral, 1% to 7% ; IM, 2% to 3%)
• Anxiety (oral, up to 16% IM, less than 4%)
• Cough (oral, adults, 2%; pediatrics, 24% ; IM, 2% to 4%)
• Nasal congestion (oral, adult, 4% to 6%; pediatric, 13%)
• Nasopharyngitis (oral, adult, 3% to 4%; pediatric, 21%)
• Pain in the throat (oral, adult, more than 5%; pediatric, 3% to 10%)
• Upper respiratory tract infection (oral, 2% to 8% ; IM, 2% and 6%)
• Fatigue (oral, adult, 1% to 3%; pediatric, 18% to 42% ; IM, 3% to 9%)
• Generalised pains (IM, 1% to 4%)
• Gynecomastia^[5]
• Galactorrhea^[6]
• Retrograde ejaculation

Rare

• Prolonged QT interval
• Sudden cardiac death
• Syncope (oral, up to 1% ; IM, up to 2%)
• Diabetic ketoacidosis
• Hypothermia
• Pancreatitis
• Agranulocytosis
• Neutropenia
• Leukopenia
• Thrombocytopenia
• Thrombotic thrombocytopenic purpura
• Stroke (oral, less than 5% ; IM, less than 4%)
• Seizure (oral, 0.3% ; IM, 0.3%)
• Tardive dyskinesia (oral, less than 5% ; IM, less than 4%)
• Priapism
• Pulmonary Embolism
• Neuroleptic Malignant Syndrome (oral, adults, less than 1%; pediatrics, less than 5%)
• Anorexia
• Hypoaesthesia
• Impaired concentration
• Sexual dysfunction
• Angioedema
• Intestinal obstruction
• Oedema
• Hyponatraemia

References

1. Truven Health Analytics, Inc. DrugPoint® System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
2. Joint Formulary Committee. British National Formulary (BNF) 65. Pharmaceutical Pr; 2013.
3. Australian Medicines Handbook 2013 [Internet]. Australian Medicines Handbook Pty. Limited; 2013. Available from: https://www.amh.net.au/online/auth?timeout&page=index.php
4. Leucht S, Cipriani A, Spineli L, Mavridis D, Örey D, Richter F, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet [Internet]. 2013 Jun 27 [cited 2013 Sep 18];382(9896):951–62. Available from: http://www.sciencedirect.com/science/article/pii/S0140673613607333
5. http://www.drugdangers.com/risperdal/gynecomastia.htm
6. "Galactorrhea - side effect of risperidone in combination with depakine chrono in a patient with bipolar disorder.". Psychiatr Danub 22: 125–7. Mar 2010. PMID 20305608.