| Name | Debut | Creator(s) | Publisher | Notes |
| Argo City | Action Comics #252 (May 1959) | | DC Comics | fictional Kryptonian city in the DC Comics Universe, and the birthplace of Supergirl. |
| Astro City | Astro City #1 (Aug 1995) | Kurt Busiek and Brent Anderson | Image Comics; later Homage Comics | A fictional American city that is the setting of the ongoing superhero series Astro City. |
| Coast City | Showcase #22 (September–October 1959) | John Broome and Gil Kane | DC Comics | Fictional Californian city and home of the Silver Age version of the superhero Green Lantern, Hal Jordan. |
| Blue Valley | The Flash #110 (December 1959) (first mentioned) | John Broome and Carmine Infantino | DC Comics | A fictional American city that is the hometown of Kid Flash, sidekick to the superhero the Flash. |
| Central City (DC Comics) | Showcase #4 (Sept–Oct 1956). | Robert Kanigher, John Broome, and Carmine Infantino | DC Comics | A fictional American city that is the home of the Silver Age Flash, Barry Allen. |
| Gotham City | Batman #4 (Winter 1940) | Bill Finger, Bob Kane | DC Comics | A fictional American city that is the home of Batman, and the principal setting for all Batman comics, films, and other adaptations. Generally portrayed as a dark, crime-ridden locale, writer/artist Frank Miller (comics) has described Gotham City as New York City at night. It was originally strongly inspired by Trenton, Ontario's history, location, atmosphere, and various architectural styles, and has since incorporated elements from New York City, Detroit, Pittsburgh, London and Chicago. Anton Furst's designs of Gotham City for Tim Burton's Batman (1989) have been influential on subsequent portrayals: he set out to "make Gotham City the ugliest and bleakest metropolis imaginable."[1] |
| Hub City | Blue Beetle #1 (June 1967) | Steve Ditko | Charlton Comics; later DC Comics | Hub City is the birthplace of controversial investigative reporter, Victor Sage – also known as the Question in the DC Universe. |
| Kandor | Action Comics #242 (July 1958) | Otto Binder and Al Plastino | DC Comics | former capital city of the fictional planet Krypton in the DC Universe. |
| Keystone City | Flash Comics #1 (January 1940) | | DC Comics | fictional city in the DC Comics Universe. Specifically, it is the home of both the original Flash, Jay Garrick, and the third Flash, Wally West. Keystone City first appeared in the 1940s in the original Flash Comics series. Within the comics, Keystone has been described as being "the blue collar capital of the United States" and a center of industry.[2] |
| Kryptonopolis | Action Comics #242 (July 1958) | | DC Comics | A fictional city in the DC Comics universe. Located on the planet Krypton, it is the birthplace of Superman. |
| Doomstadt | Fantastic Four Volume 1 #5 (1962) | Stan Lee, Jack Kirby | Marvel Comics | Doomstadt is a capital city of a fictional country, Latveria, in the Marvel Comics Universe. Its original name was Hassenstadt before Doctor Doom became dictator of the country. Doomstadt had also appeared in the film adaptation of Fantastic four comics, Fantastic Four: Rise of the Silver Surfer, but the name was just Hassenstadt. |
| Madripoor | New Mutants #32 (Oct 1985) | Chris Claremont and Steve Leialoha | Marvel Comics | The principal city of a small southeast Asian country of the same name, similar to Singapore. It has an extreme divide between the wealthy and poor, and an extensive criminal underworld. |
| Mega-City One | 2000 AD #2 (March 5, 1977) | John Wagner | | A huge fictional city-state covering much of what is now the Eastern United States in the Judge Dredd comic book series. The exact boundaries of the city depend on which artist has drawn the story. The city seems to have grown outward from the present-day Northeast megalopolis, extending to the Atlanta metropolitan area southwards, and the Quebec City-Windsor Corridor northwards. |
| Metropolis | Action Comics #16 (Sept 1939) | | DC Comics | A fictional American city that is the home of Superman, and along with Smallville, one of the principal settings for all Superman comics, films, and other adaptations. |
| Midway City | The Brave and the Bold #34 (Feb–Mar 1961) | Gardner Fox, Joe Kubert | DC Comics | fictional Midwestern city based loosely on the real world city of Chicago, Illinois and once home of the Silver Age Hawkman and Hawkgirl. |
| Rajnagar | - | - | Raj Comics | A fictional city usually appearing in the comic book published by Raj Comics. |
| Riverdale | | Bob Montana | Archie Comics | A fictional American town that is the principal setting for the various Archie Comics titles and characters. |
| Savage Land | X-Men #10 (March 1965) | Stan Lee, Jack Kirby | Marvel Comics | The Savage Land is a hidden fictional prehistoric land within the Marvel Comics Universe. It is a tropical preserve hidden in Antarctica. |
| Smallville | Superboy #2 (May 1949) | | DC Comics | A fictional town in the American Midwest (often placed in Kansas) that is the hometown of Superman, where he landed on earth as an infant and was raised under an ordinary human identity in a small, idyllic farming community. Comics and adapted media that portray Superman's origin typically show his growing up in Smallville (such as Superman (1978)), and the adult Superman also returns to visit. Smallville debuted in comics as the setting for Superboy (originally the identity of Superman as a youth, later made into a separate character) but was first mentioned in The Adventures of Superman radio show. The television series Smallville broadcast from 2001 to 2011. |
| Star City | Green Arrow (vol. 3) #60 (May 2006) | | DC Comics | Star City, called Starling City in the Arrow TV show, is a fictional city that appears in stories published by DC Comics, best known as the traditional home of the superheroes known by, or affiliated with, the shared alias of Green Arrow. Beyond that, it is also known to other characters of the DC Universe as both a port city and a haven for artists in many of the media, from print to audio-visual to music. |
| Symkaria | The Amazing Spider-Man#265 | Tom DeFalco | Marvel Comics | Symkaria is a fictional Eastern European country in the Marvel Universe. It is one of several fictional countries in Eastern Europe created by Marvel Comics. The fictional country is mostly known as being the home of Silver Sable and the Wild Pack team though it is used throughout the Marvel Universe. The country has appeared in issues of Silver Sable, Silver Sable and the Wild Pack, The Amazing Spider-Man, Thunderbolts, Citizen V and the V-Battalion, and other comics published by Marvel Comics. |
| The City | Transmetropolitan #1 | Warren Ellis and Darick Robertson | DC Comics | fictional megacity which forms the main setting for the Vertigo comic Transmetropolitan by Warren Ellis. Located somewhere in the United States, the City is the largest metropolitan area in the futuristic world of the series (an exact date is never given), and the center of political and social culture. |