| Artist | Single | Reached #1 | Weeks |
|---|
| Joe McElderry | "The Climb" |
000000002009-12-19-000019 December 2009 | 4 |
| Lady Gaga | "Bad Romance" |
000000002010-01-14-000014 January 2010 | 1 |
| Owl City | "Fireflies" |
000000002010-01-21-000021 January 2010 | 2 |
| Jedward featuring Vanilla Ice | "Under Pressure (Ice Ice Baby)" |
000000002010-02-04-00004 February 2010 | 1 |
| Helping Haiti | "Everybody Hurts" |
000000002010-02-11-000011 February 2010 | 1 |
| Jedward featuring Vanilla Ice | "Under Pressure (Ice Ice Baby)" |
000000002010-02-18-000018 February 2010 | 2 |
| Boyzone | "Gave It All Away" |
000000002010-03-04-00004 March 2010 | 1 |
| Jedward featuring Vanilla Ice | "Under Pressure (Ice Ice Baby)" |
000000002010-03-11-000011 March 2010 | 1 |
| Boyzone | "Gave It All Away" |
000000002010-03-18-000018 March 2010 | 1 |
| Lady Gaga featuring Beyoncé | "Telephone" |
000000002010-03-25-000025 March 2010 | 4 |
| Glee Cast | "Gives You Hell" |
000000002010-04-22-000022 April 2010 | 1 |
| Usher featuring will.i.am | "OMG" |
000000002010-04-29-000029 April 2010 | 2 |
| Train | "Hey, Soul Sister" |
000000002010-05-13-000013 May 2010 | 1 |
| Alexandra Burke featuring Pitbull | "All Night Long" |
000000002010-05-20-000020 May 2010 | 1 |
| Edward Maya & Vika Jigulina | "Stereo Love" |
000000002010-05-27-000027 May 2010 | 4 |
| Katy Perry featuring Snoop Dogg | "California Gurls" |
000000002010-06-24-000024 June 2010 | 4 |
| Eminem featuring Rihanna | "Love the Way You Lie" |
000000002010-07-22-000022 July 2010 | 1 |
| Yolanda Be Cool & DCUP | "We No Speak Americano" |
000000002010-07-29-000029 July 2010 | 1 |
| Flo Rida featuring David Guetta | "Club Can't Handle Me" |
000000002010-08-05-00005 August 2010 | 1 |
| Eminem featuring Rihanna | "Love the Way You Lie" |
000000002010-08-12-000012 August 2010 | 2 |
| Taio Cruz | "Dynamite" |
000000002010-08-26-000026 August 2010 | 1 |
| Katy Perry | "Teenage Dream" |
000000002010-09-02-00002 September 2010 | 1 |
| The Script | "For the First Time" |
000000002010-09-09-00009 September 2010 | 3 |
| Tinie Tempah featuring Eric Turner | "Written in the Stars" |
000000002010-09-30-000030 September 2010 | 1 |
| Bruno Mars | "Just the Way You Are" |
000000002010-10-07-00007 October 2010 | 3 |
| Cheryl Cole | "Promise This" |
000000002010-10-28-000028 October 2010 | 1 |
| Rihanna | "Only Girl (In the World)" |
000000002010-11-04-00004 November 2010 | 3 |
| The X Factor Finalists 2010 | "Heroes" |
000000002010-11-25-000025 November 2010 | 3 |
| Matt Cardle | "When We Collide" |
000000002010-12-17-000017 December 2010 | 4 |
|