List of side effects of tramadol

The most common side effects of tramadol in order of decreasing incidence are:^{[1][2][3][4][5][6][7]}
Note: Serious adverse effects are in bold.

Very common (>10% frequency)

• Dizziness
• Nausea
• Constipation
• Vertigo
• Headache
• Vomiting
• Somnolence

Common (1–10% frequency)

• Agitation
• Anxiety
• Emotional lability
• Euphoria
• Nervousness
• Spasticity
• Dyspepsia (indigestion)
• Asthenia (weakness)
• Pruritus (itchiness)
• Dry mouth
• Diarrhea
• Fatigue
• Sweating
• Malaise
• Vasodilation (dilation (widening) of blood vessels)
• Confusion
• Coordination disturbance
• Miosis
• Sleep disorder
• Rash
• Hypertonia
• Abdominal pain
• Weight loss
• Visual disturbance
• Flatulence
• Menopausal symptoms
• Urinary frequency
• Urinary retention (being unable to urinate)

Uncommon (0.1-1% incidence)

• Cardiovascular regulation anomalies (palpitation, tachycardia, postural hypotension or cardiovascular collapse)
• Retching
• Gastrointestinal irritation (a feeling of pressure in the stomach, bloating)
• Urticaria (hives)
• Trembling
• Flushing

Rare (0.01–0.1% incidence)

• Bradycardia
• Hypertension (high blood pressure)
• Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema)
• Anaphylaxis
• Changes in appetite
• Paraesthesia (pins and needles)
• Hallucinations
• Tremor
• Respiratory depression
• Epileptiform convulsions
• Involuntary muscle contractions
• Abnormal coordination
• Syncope (fainting)
• Blurred vision
• Dyspnoea (shortness of breath)
• Tinnitus (ringing in the ears)
• Migraine
• Stevens-Johnson syndrome/Toxic epidermal necrolysis (potentially fatal skin reactions)
• Motorial weakness
• Creatinine increase
• Elevated liver enzymes
• Hepatitis (liver swelling)
• Stomatitis (mouth swelling)
• Liver failure
• Pulmonary oedema (fluid in the lungs)
• Gastrointestinal bleeding
• Pulmonary embolism
• Myocardial ischaemia (lack of blood supply to the heart muscles)
• Speech disorders
• Haemoglobin decrease
• Proteinuria (protein in the urine; usually indicative of kidney damage)

References

1. ↑ "Ultram, Ultram ER (tramadol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 28 November 2013.
2. ↑ "PRODUCT INFORMATION Tramadol SANDOZ 50 mg capsules" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 4 November 2011. Retrieved 6 April 2014.
3. ↑ "Tramadol Hydrochloride 50mg Capsules – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 12 June 2013. Retrieved 28 November 2013.
4. ↑ "Tilodol SR 100 mg Prolonged-Release Tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 6 March 2013. Retrieved 28 November 2013.
5. ↑ "PRODUCT INFORMATION TRAMADOL SANDOZ® SR 100MG, 150MG and 200MG SUSTAINED RELEASE TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 21 November 2013. Retrieved 28 November 2013.
6. ↑ "ULTRAM (TRAMADOL HYDROCHLORIDE) TABLET, COATED [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". DailyMed. LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC. November 2012. Retrieved 28 November 2013.
7. ↑ "ULTRAM ER (TRAMADOL HYDROCHLORIDE) TABLET, EXTENDED RELEASE [REBEL DISTRIBUTORS CORP]". DailyMed. Rebel Distributors Corp. December 2010. Retrieved 28 November 2013.