List of target antigens in pemphigoid

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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.

Target antigens for the different pemphigoid variants
Pemphigoid variant Antibody isotype Antigen Molecular weight (KDa)
Bullous pemphigoid IgG, IgE[1] NC16A terminal of BPAG2
BPAG1 		180
230
Herpes gestationis IgG1 NC16A terminal of BPAG2
BPAG1 		180
230
Cicatricial pemphigoid C-terminal of BPAG2 180
Ocular cicatricial pemphigoid Integrin beta-4 subunit 200
Antiepiligrin cicatricial pemphigoid[nb 1] Laminin 5 (Epiligrin, Laminin 332)
Linear IgA bullous dermatosis LAD1 portion of BPAG2
Collagen type VII
 97
290/145
Protein 105 pemphigoid Protein in lower lamina lucida 105

Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:

Target antigens for the different autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system, excluding pemphigoid
Disease Antibody isotype Antigen Molecular weight (KDa)
Epidermolysis bullosa acquisita Collagen type VII 290/145
Bullous lupus erythematosus Collagen type VII 290/145
Lichen planus pemphigoides[nb 2] BPAG2 180

Footnotes

  1. ↑ The antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer.
  2. ↑ In this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus.

See also

References

  1. ↑ http://archderm.jamanetwork.com/article.aspx?articleid=1392581
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