Long-acting reversible contraception

Long-acting reversible contraceptives (LARC) are methods of birth control that provide effective contraception for an extended period without requiring user action. They include injections, intrauterine devices (IUDs) and subdermal contraceptive implants. They are the most effective reversible methods of contraception because they do not depend on patient compliance. So their 'typical use' failure rates, at less than 1% per year, are about the same as 'perfect use' failure rates.[1]

In addition to being long-lasting, convenient, and well liked by users, they are very cost effective.[1] Typically, LARC users can save thousands of dollars over a five-year period compared to the use of condoms and birth control pills.[2] Despite their safety and effectiveness LARCs are underutilized: only 15.5% of women worldwide use IUDs, and only 3.4% use subdermal implants.[2]

Long-acting reversible contraception is recommended for adolescents[3] to help decrease the teen pregnancy rate.[4] LARCs are recommended for women of any age no matter how many times they have given birth.[5] Women considering using LARCs should obtain contraceptive counseling from reproductive health professionals because those who do are more satisfied with them and use them for longer periods of time.[2]

Methods

Available LARC methods include IUDs and the subdermal implant:

Some shorter-acting methods are sometimes considered LARC:

Efficacy

The effectiveness of LARC methods has been shown to be superior to other types of birth control.[6] [7] A study in 2012, with the largest cohort of IUD and implant users to date, found that the risk of contraceptive failure for those using oral contraceptive pills, the birth control patch, or the vaginal ring was 17 to 20 times higher than the risk for those using long-acting reversible contraception.[7] For those under 21, who typically have lower adherence to drug regimens, the risk is twice as high as the risk among older participants.[7] A statistically significant association has been observed in England between a decrease in teenage conception and increased LARC usage.[8]

The discrepancy between LARC methods and other forms of birth control lies in the difference between "perfect use" and "typical use". Perfect use indicates complete adherence to medication schedules and guidelines. Typical use describes effectiveness in real-world conditions, where patients may not fully adhere to medication regimens. LARC methods require little to no user action after insertion; therefore, LARC perfect use failure rates are the same as their typical use failure rates.[9] LARC failure rates rival that of sterilization, but unlike sterilization LARC methods are reversible.[9] Other reversible methods, such as oral contraceptive pills, the birth control patch, or the vaginal ring require daily, weekly, or monthly action by the user. While the perfect use failure rates of those methods may equal LARC methods, the typical use failure rates are significantly higher.[10] Even methods such as the DMPA injection require users to return to their provider every 12 weeks for the intramuscular shot or every 4 weeks for the subcutaneous shot. So, DMPA typical use failure rates are also higher than perfect use failure rates as more than 40% of women discontinue DMPA in the first year.[11] In both effectiveness and continuation, LARC methods are considered the first-line option for contraception.[7]

Cost

LARC methods traditionally have a higher up-front cost, between $800 and $900 in the United States,[12] as compared to other methods such as oral contraceptive pills, the patch, and the vaginal ring. However, LARC methods are some of the most cost-effective in the long term.[13] Like all contraceptive methods, access to LARC methods can reduce the rate of unintended pregnancy and result in significant cost savings to publicly funded health systems.[13] Women switching from short-acting reversible contraceptive to long-acting intrauterine systems are likely to generate cost savings from unplanned pregnancy-related expenses and long term savings in contraceptive costs.[14] Regardless, the initial out of pocket cost is still too high for many patients and is one of the biggest barriers to LARC use. Two recent studies done in California and St. Louis have shown that rates of LARC usage are dramatically higher when the costs of the methods are either covered or removed.[15][16][17] A program geared toward increasing use of LARC among adolescents in Iowa demonstrated a significant decrease in the unintended pregnancy and abortion rate in that state along with a projected savings of $17.23 for every dollar spent on contraception for 14- to 19-year-olds.[18] A 6 year program in Colorado funded by a private grant decreased unplanned adolescent pregnancies in the state by about 40% and returned $5 in savings for each dollar spent. There was a similar decline of unplanned pregnancies in unmarried women under 25 who have not finished high school, another at risk group. Use of LARC methods by children of child-bearing age in the state increased to 20% during the 2009-2014 period.[12]

Promotion

LARC usage[19]
Russia 32%
France 27%
Austria 23%
Georgia 23%
Bulgaria 18%
Germany 11%
Romania 10%
United States 10%
Australia 7%

The United Kingdom Department of Health has actively promoted LARC use since 2008, particularly for young people;[20] following on from the October 2005 National Institute for Health and Clinical Excellence guidelines, which promoted LARC provision in the United Kingdom, accurate and detailed counseling for women about these methods, and training of healthcare professionals to provide these methods.[21] Giving advice on these methods of contraception has been included in the 2009 Quality and Outcomes Framework "good practice" for primary care.[22]

The use of long-acting reversible contraceptives in the United States has increased nearly fivefold from 1.5% in 2002 to 7.2% in 2011–2013.[23] Increasing access to long-acting reversible contraceptives was listed by the Centers for Disease Control and Prevention as one of the top public health priorities for reducing teen pregnancy and unintended pregnancy in the United States.[24] One study of female family planning providers showed that they were significantly more likely to use LARCs than the general population (41.7% compared to 12.0%) suggesting that the general population has less information or access to LARCs.[25]

Guidelines released in 2009 by the American Congress of Obstetricians and Gynecologists state that LARC methods are considered to be the first-line option for birth control in the United States, and are recommended for the majority of women.[26] According to the CDC Medical Eligibility Criteria for Contraceptive Use, LARC methods are recommended for the majority of women who have had their first menstruation, regardless of whether they have had any pregnancies.[27] The American Academy of Pediatrics (AAP) in a policy statement and technical report[28] published in October 2014 recommended LARC methods for adolescents.[3]

Contraindications, risks and side effects

Contraceptive implants may cause irregular bleeding which some women find unacceptable as a side-effect[29] ("Irregular bleeding and spotting common in first 6 months" associated with IUS; similar to side-effects observed with IUD, injection or implant. "Changes in bleeding pattern which are likely to remain irregular")[30] or a complete cessation of menstrual flow (amenorrhea). Side effects that are observed less often may include emotional lability, weight gain, headache, and acne.[28]

Side-effects for LARC are mostly similar to combined and progesterone only oral contraceptives, with a possibility of a small change in mood or libido observed in IUD and IUS use.[30] The risk of acne vulgaris may be higher in IUS users, but is an uncommon reason for stopping use.[30] Weight gain has been observed with Depo Provera usage. IUDs present a slight risk of infection at the time of insertion[28] but have a low risk of pelvic inflammatory disease (<1% for women at low risk of STIs), and uterine perforation (<1 in 1000).[30] If a person becomes pregnant while they have an IUD inserted then the IUD should be removed within the first 12 weeks of gestation. In such a case, the mother has low risk of ectopic pregnancy - approximately 1 in 20 (lower than with no contraception).[30] Women who cease using Depo Provera can find that they have a delay of up to a year before being able to get pregnant, while there is no evidence of a delay in IUD, IUS or implant users.[30]

References

  1. 1 2 Stoddard, A.; McNicholas, C.; Peipert, J. F. (2011). "Efficacy and Safety of Long-Acting Reversible Contraception". Drugs 71 (8): 969–980. doi:10.2165/11591290-000000000-00000. PMID 21668037.
  2. 1 2 3 Blumenthal, P. D.; Voedisch, A.; Gemzell-Danielsson, K. (2010). "Strategies to prevent unintended pregnancy: Increasing use of long-acting reversible contraception". Human Reproduction Update 17 (1): 121–137. doi:10.1093/humupd/dmq026. PMID 20634208.
  3. 1 2 Mary A. Ott and Gina S. Sucato, lead authors for the Committee on Adolescence (1 October 2014). "From the American Academy of Pediatrics Policy Statement Contraception for Adolescents". Pediatrics (American Academy of Pediatrics (AAP)) 134 (4): e1244 –e1256. doi:10.1542/peds.2014-2299. Retrieved 7 July 2015. LARC methods should be considered first-line contraceptive choices for adolescents.
  4. ↑ Rowan, S. P.; Someshwar, J.; Murray, P. (2012). "Contraception for primary care providers". Adolescent medicine: state of the art reviews 23 (1): 95–110, x–xi. PMID 22764557.
  5. ↑ Mestad, R.; Kenerson, J.; Peipert, J. (2009). "Reversible Contraception Update: The Importance of Long-Acting Reversible Contraception" (PDF). Postgraduate Medicine 121 (4): 18–25. doi:10.3810/pgm.2009.07.2025. PMC 3164772. PMID 19641264.
  6. ↑ Mavranezouli, I.; Group, on behalf of the LARC Guideline Development (2008), "The cost-effectiveness of long-acting reversible contraceptive methods in the UK: analysis based on a decision-analytic model developed for a National Institute for Health and Clinical Excellence (NICE) clinical practice guideline", Human Reproduction 23 (6): 1338–1345, doi:10.1093/humrep/den091, PMID 18372257
  7. 1 2 3 4 Winner, B; Peipert, JF; Zhao, Q; Buckel, C; Madden, T; Allsworth, JE; Secura, GM. (2012), "Effectiveness of Long-Acting Reversible Contraception", New England Journal of Medicine 366 (21): 1998–2007, doi:10.1056/NEJMoa1110855, PMID 22621627
  8. ↑ Connolly A, Pietri G, Yu J, Humphreys S (2014). "Association between long-acting reversible contraceptive use, teenage pregnancy, and abortion rates in England.". Int J Womens Health 6: 961–74. doi:10.2147/IJWH.S64431. PMC 4247139. PMID 25473316.
  9. 1 2 Trussel, J (2007), ""Effectiveness of Long-Acting Reversible Contraception" In:Hatcher, RA; Nelson, TJ; Guest, F; Kowal, D.", Contraceptive Technology 19th ed. (New York: Ardent Media)
  10. ↑ Kost, K; Singh, S; Vaughan, B; Trussel, J; Bankole, A (2008), "Estimates of Contraceptive Failure from the 2002 National Survey of Family Growth", Contraception 77: 10–21, doi:10.1016/j.contraception.2007.09.013, PMC 2811396, PMID 18082661
  11. ↑ Peipert, JF; Zhao, Q; Allsworth, JE (2011), "Continuation and satisfaction of reversible contraception", Obstet Gynecol 117: 1105–13, doi:10.1097/aog.0b013e31821188ad
  12. 1 2 Sabrina Tavernise (5 July 2015). "Colorado’s Effort Against Teenage Pregnancies Is a Startling Success". The New York Times. Retrieved 7 July 2015. The state health department estimated that every dollar spent on the long-acting birth control initiative saved $5.85 for the state’s Medicaid program, which covers more than three-quarters of teenage pregnancies and births.
  13. 1 2 Cleland, K; Peipert, JF; Spear, S; Trussel, J (2011), "Family Planning as a Cost-Saving Preventive Health Service", New England Journal of Medicine 364 (37): e37, doi:10.1056/NEJMp1104373, PMID 21506736
  14. ↑ Trussell J, Hassan F, Henry N, Pocoski J, Law A, Filonenko A (2014). "Cost-effectiveness analysis of levonorgestrel-releasing intrauterine system (LNG-IUS) 13.5 mg in contraception.". Contraception 89 (5): 451–9. doi:10.1016/j.contraception.2013.10.019. PMC 4019682. PMID 24576791.
  15. ↑ Postlethwaite, D; Trussel, J; Zoolakis, A; Shabear, R; Petittie, D (2007), "A comparison of contraceptive procurement pre- and post-benefit change", Contracpetion 76: 360–5, doi:10.1016/j.contraception.2007.07.006
  16. ↑ Secura, GM; Allsworth, JE; Madden, T; Mullersman, JL; Peipert, JF (2010), "The Contraceptive CHOICE Project: reducing barriers to long-acting reversible contraception", American Journal of Obstetrics & Gynecology 115 (e1): 115.e1–115.e7, doi:10.1016/j.ajog.2010.04.017
  17. ↑ Secura GM, Madden T, McNicholas C, Mullersman J, Buckel CM, Zhao Q, et al. (2014). "Provision of no-cost, long-acting contraception and teenage pregnancy.". N Engl J Med 371 (14): 1316–23. doi:10.1056/NEJMoa1400506. PMC 4230891. PMID 25271604.
  18. ↑ Udeh, B; Losch, M; Spies, E (2009), The Cost of Unintended Pregnancy in Iowa: A Benefit-Cost Analysis of Public Funded Family Planning Services, The University of Iowa Public Policy Center
  19. ↑ Eeckhaut MC, Sweeney MM, Gipson JD (2014). "Who is using long-acting reversible contraceptive methods? Findings from nine low-fertility countries.". Perspect Sex Reprod Health 46 (3): 149–55. doi:10.1363/46e1914. PMC 4167921. PMID 25040454.
  20. ↑ "Increasing use of long-acting reversible contraception". Nursing Times.net. 21 October 2008. Retrieved 2009-06-19.
  21. ↑ "CG30 Long-acting reversible contraception: quick reference guide" (PDF). National Institute for Health and Clinical Excellence. Retrieved 2009-06-19.
  22. ↑ "Sexual Health Ruleset" (PDF). New GMS Contract Quality and Outcome Framework - Implementation Dataset and Business Rules. Primary Care Commissioning. 1 May 2009. Retrieved 2009-06-19.
    Summarised at
    * "Contraception - Management QOF indicators". NHS Clinical Knowledge Summaries. NHS Institute for Innovation and Improvement. Retrieved 2009-06-19.
  23. ↑ Branum A, Jones J (2015). "Trends in Long-acting Reversible Contraception Use Among U.S. Women Aged 15-44." (PDF). NCHS Data Brief (188): 1–8. PMID 25714042.
  24. ↑ "Public Health Priorities". Centers for Disease Control and Prevention. 20 September 2011.
  25. ↑ Stern LF, Simons HR, Kohn JE, Debevec EJ, Morfesis JM, Patel AA (2015). "Differences in Contraceptive Use Between Family Planning Providers and the U.S. Population: Results of a Nationwide Survey.". Contraception 91: 464–9. doi:10.1016/j.contraception.2015.02.005. PMID 25722074.
  26. ↑ ACOG Committee Opinion 450 (December 2009). "Increasing the Use of Contraceptive Implants and Intrauterine Devices To Reduce Unintended Pregnancy". American Congress of Obstetricians and Gynecologists. Retrieved 2012-06-28.
  27. ↑ "U.S. Medical Eligibility Criteria for Contraceptive Use, 2010" (PDF). Morbidity and Mortality Weekly Report. Centers for Disease Control and Prevention. 28 May 2010.
  28. 1 2 3 Mary A. Ott, Gina S. Sucato, Committee ON Adolescence (1 October 2014). "From the American Academy of Pediatrics Technical Report Contraception for Adolescents" (Text and PDF). Pediatrics (American Academy of Pediatrics) 134 (4): e1257 –e1281. doi:10.1542/peds.2014-2300. Retrieved 7 July 2015. For adolescents who need highly effective contraception that is user- and coitus-independent, the implant is an outstanding choice.
  29. ↑ "Managing Clinical Complexities of Long-Term Contraception". Medscape. Retrieved 27 February 2016.
  30. 1 2 3 4 5 6 "UKMi Guidance: Long-acting reversible contraception (update)" (PDF). NHS. Retrieved 23 November 2014.

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