Loviride

Loviride

Systematic (IUPAC) name
2-[(2-Acetyl-5-methylphenyl)amino]-2-(2,6-dichlorophenyl)acetamide
Identifiers
ATC code	none
PubChem	CID 3963
ChemSpider	3826
UNII	3S1R1LZ09H
KEGG	D04786
ChEMBL	CHEMBL37624
Synonyms	R089439
Chemical data
Formula	C17H16Cl2N2O2
Molar mass	351.227 g/mol
SMILES Clc1cccc(Cl)c1C(Nc2cc(ccc2C(=O)C)C)C(=O)N
InChI InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23) Key:CJPLEFFCVDQQFZ-UHFFFAOYSA-N
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Loviride (also called loveride) was an antiviral drug manufactured by Janssen (now part of Janssen-Cilag) that is active against HIV. Loviride is an Non-nucleoside reverse transcriptase inhibitor (NNRTI) that entered phase III clinical trials in the late 1990s but failed to gain marketing approval because of poor potency. It is of clinical significance only in those patients who were enrolled in clinical trials to evaluate loviride (e.g., CAESAR and AVANTI), because in those trials loviride was often given alone and with no companion drug, leading to a high probability of developing reverse transcriptase mutations such as K103N which result in cross-class resistance the NNRTIs efavirenz and nevirapine.

Synthesis

Loviride synthesis: Janssen Pharmaceutica U.S. Patent 5,407,961 (1995).

External links

• aidsmap