Lupeol synthase

Lupeol synthase
Identifiers
EC number	5.4.99.41
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Lupeol synthase (EC 5.4.99.41, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming).^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene $\rightleftharpoons$ lupeol

Also forms some beta-amyrin.

References

1. Herrera, J.B., Bartel, B., Wilson, W.K. and Matsuda, S.P. (1998). "Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene". Phytochemistry 49: 1905–1911. doi:10.1016/s0031-9422(98)00366-5. PMID 9883589.
2. Shibuya, M., Zhang, H., Endo, A., Shishikura, K., Kushiro, T. and Ebizuka, Y. (1999). "Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases". Eur. J. Biochem. 266: 302–307. doi:10.1046/j.1432-1327.1999.00875.x. PMID 10542078.
3. Segura, M.J., Meyer, M.M. and Matsuda, S.P. (2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Org. Lett. 2: 2257–2259. doi:10.1021/ol006016b. PMID 10930257.
4. Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. doi:10.1248/bpb.26.642. PMID 12736505.
5. Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. doi:10.1248/bpb.27.1086. PMID 15256745.
6. Guhling, O., Hobl, B., Yeats, T. and Jetter, R. (2006). "Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis". Arch. Biochem. Biophys. 448: 60–72. doi:10.1016/j.abb.2005.12.013. PMID 16445885.
7. Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.

External links

• Lupeol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)