Lysine dehydrogenase

lysine dehydrogenase
Identifiers
EC number	1.4.1.15
CAS number	68073-29-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a lysine dehydrogenase (EC 1.4.1.15) is an enzyme that catalyzes the chemical reaction

L-lysine + NAD⁺ $\rightleftharpoons$ 1,2-didehydropiperidine-2-carboxylate + NH₃ + NADH + H⁺

Thus, the two substrates of this enzyme are L-lysine and NAD⁺, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).

References

• Burgi W, Richterich R, Colombo JP (1966). "L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance". Nature. 211 (5051): 854–5. doi:10.1038/211854a0. PMID 4291003.