MAD1L1

MAD1 mitotic arrest deficient-like 1 (yeast)
PDB rendering based on 1go4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GO4​, 4DZO​
Identifiers
Symbols	MAD1L1 ; MAD1; PIG9; TP53I9; TXBP181
External IDs	OMIM: 602686 MGI: 1341857 HomoloGene: 74500 GeneCards: MAD1L1 Gene
Gene ontology Molecular function • protein binding Cellular component • kinetochore • condensed chromosome kinetochore • spindle pole • nucleus • nuclear pore • cytoplasm • centrosome • spindle • cytosol • actin cytoskeleton • mitotic spindle Biological process • mitotic cell cycle • mitotic nuclear division • mitotic cell cycle checkpoint • mitotic spindle assembly checkpoint • small GTPase mediated signal transduction • negative regulation of T cell proliferation • thymus development • cell division • regulation of metaphase plate congression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8379	17120
Ensembl	ENSG00000002822	ENSMUSG00000029554
UniProt	Q9Y6D9	Q9WTX8
RefSeq (mRNA)	NM_001013836	NM_010752
RefSeq (protein)	NP_001013858	NP_034882
Location (UCSC)	Chr 7: 1.82 – 2.23 Mb	Chr 5: 140.01 – 140.32 Mb
PubMed search

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.^[1][2][3]

MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.

Function

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

MAD1L1 has been shown to interact with:

• HDAC1,^[4]
• Histone deacetylase 2,^[4] and
• MAD2L1,^[5][6][7]

See also

• MAD1
• MAD2
• Hyperphosphorylation

References

1. Jin DY, Kozak CA, Pangilinan F, Spencer F, Green ED, Jeang KT (May 1999). "Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5". Genomics 55 (3): 363–4. doi:10.1006/geno.1998.5654. PMID 10049595.
2. Jin DY, Spencer F, Jeang KT (May 1998). "Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1". Cell 93 (1): 81–91. doi:10.1016/S0092-8674(00)81148-4. PMID 9546394.
3. "Entrez Gene: MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)".
4. Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. 575 (1-3): 23–9. doi:10.1016/j.febslet.2004.07.089. PMID 15388328.
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
6. Sironi L, Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22): 6371–82. doi:10.1093/emboj/20.22.6371. PMC 125308. PMID 11707408.
7. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. PMID 10660610.