MAGEA12

Melanoma antigen family A12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1QEW​
Identifiers
Symbols	MAGEA12 ; CT1.12; MAGE12
External IDs	OMIM: 300177 HomoloGene: 88720 GeneCards: MAGEA12 Gene
Gene ontology Molecular function • molecular_function Cellular component • cellular_component Biological process • biological_process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4111	n/a
Ensembl	ENSG00000213401	n/a
UniProt	P43365	n/a
RefSeq (mRNA)	NM_001166386	n/a
RefSeq (protein)	NP_001159858	n/a
Location (UCSC)	Chr X: 152.73 – 152.74 Mb	n/a
PubMed search		n/a

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.^[1][2]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[2]

References

1. Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–731. doi:10.1006/geno.1995.9945. PMID 8575766.
2. "Entrez Gene: MAGEA12 melanoma antigen family A, 12".

Further reading

• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics 40 (5): 360–369. doi:10.1007/BF01246677. PMID 7927540. replacement character in |last8= at position 5 (help)
• Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes". Biochem. Biophys. Res. Commun. 202 (1): 549–555. doi:10.1006/bbrc.1994.1963. PMID 8037761.
• De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics 39 (2): 121–9. doi:10.1007/bf00188615. PMID 8276455.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–775. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Wischnewski F, Friese O, Pantel K, Schwarzenbach H (2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Mol. Cancer Res. 5 (7): 749–759. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.