MAGEA9
| Melanoma antigen family A9 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MAGEA9 ; CT1.9; MAGE9 | ||||||||||||
| External IDs | OMIM: 300342 HomoloGene: 129593 GeneCards: MAGEA9 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4108 | n/a | |||||||||||
| Ensembl | ENSG00000123584 | n/a | |||||||||||
| UniProt | P43362 | n/a | |||||||||||
| RefSeq (mRNA) | NM_005365 | n/a | |||||||||||
| RefSeq (protein) | NP_005356 | n/a | |||||||||||
| Location (UCSC) |
Chr X: 149.78 – 149.79 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene.[1][2]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[2]
References
- ↑ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
- 1 2 "Entrez Gene: MAGEA9 melanoma antigen family A, 9".
Further reading
- Oehlrich N, Devitt G, Linnebacher M, et al. (2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma.". Int. J. Cancer 117 (2): 256–64. doi:10.1002/ijc.21200. PMID 15900605.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lee JH, Sung BW, Youn HJ, Park JH (2001). "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen". Mol. Cells 10 (6): 647–53. doi:10.1007/s10059-000-0647-7. PMID 11211869.
- Serrano A, Lethé B, Delroisse JM, et al. (1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". Int. J. Cancer 83 (5): 664–9. doi:10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V. PMID 10521804.
- Timms KM, Bondeson ML, Ansari-Lari MA, et al. (1997). "Molecular and phenotypic variation in patients with severe Hunter syndrome". Hum. Mol. Genet. 6 (3): 479–86. doi:10.1093/hmg/6.3.479. PMID 9147653.
- De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
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