MAGEB2

Melanoma antigen family B2
Identifiers
Symbols	MAGEB2 ; CT3.2; DAM6; MAGE-XP-2
External IDs	OMIM: 300098 MGI: 3584456 HomoloGene: 134515 GeneCards: MAGEB2 Gene
Gene ontology Molecular function • protein binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4113	434903
Ensembl	ENSG00000099399	ENSMUSG00000035427
UniProt	O15479	A2A9R3
RefSeq (mRNA)	NM_002364	NM_001033492
RefSeq (protein)	NP_002355	NP_001028664
Location (UCSC)	Chr X: 30.22 – 30.22 Mb	Chr X: 86.25 – 86.31 Mb
PubMed search

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.^[1][2]

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.^[2]

References

1. Lurquin C, De Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, Brasseur R, Monaco AP, Boon T (Mar 1998). "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins". Genomics 46 (3): 397–408. doi:10.1006/geno.1997.5052. PMID 9441743.
2. "Entrez Gene: MAGEB2 melanoma antigen family B, 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Dabovic B, Zanaria E, Bardoni B, et al. (1996). "A family of rapidly evolving genes from the sex reversal critical region in Xp21.". Mamm. Genome 6 (9): 571–80. doi:10.1007/BF00352360. PMID 8535061.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• McCurdy DK, Tai LQ, Nguyen J, et al. (1998). "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera.". Mol. Genet. Metab. 63 (1): 3–13. doi:10.1006/mgme.1997.2639. PMID 9538511.
• Lee JH, Sung BW, Youn HJ, Park JH (2001). "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen.". Mol. Cells 10 (6): 647–53. doi:10.1007/s10059-000-0647-7. PMID 11211869.
• Park JH, Lee SW (2003). "Hypertonicity induction of melanoma antigen, a tumor-associated antigen.". Mol. Cells 13 (2): 288–95. PMID 12018852.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Milutinovic S, D'Alessio AC, Detich N, Szyf M (2007). "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.". Carcinogenesis 28 (3): 560–71. doi:10.1093/carcin/bgl167. PMID 17012225.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.