MAGEC2

Melanoma antigen family C2
Identifiers
Symbols	MAGEC2 ; CT10; HCA587; MAGEE1
External IDs	OMIM: 300468 HomoloGene: 130677 GeneCards: MAGEC2 Gene
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding Cellular component • nucleus • cytoplasm Biological process • cellular protein catabolic process • positive regulation of ubiquitin-protein transferase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51438	n/a
Ensembl	ENSG00000046774	n/a
UniProt	Q9UBF1	n/a
RefSeq (mRNA)	NM_016249	n/a
RefSeq (protein)	NP_057333	n/a
Location (UCSC)	Chr X: 142.2 – 142.21 Mb	n/a
PubMed search		n/a

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.^[1][2]

This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.^[2]

References

1. Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (Mar 2000). "CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis". Int J Cancer 85 (5): 726–32. doi:10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F. PMID 10699956.
2. "Entrez Gene: MAGEC2 melanoma antigen family C, 2".

Further reading

• Lucas S, De Plaen E, Boon T (2000). "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.". Int. J. Cancer 87 (1): 55–60. doi:10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.0.CO;2-J. PMID 10861452.
• Sasaki M, Nakahira K, Kawano Y, et al. (2001). "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma.". Cancer Res. 61 (12): 4809–14. PMID 11406556.
• Kawano Y, Sasaki M, Nakahira K, et al. (2001). "Structural characterization and chromosomal localization of the MAGE-E1 gene.". Gene 277 (1-2): 129–37. doi:10.1016/S0378-1119(01)00698-9. PMID 11602350.
• Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li B, Qian XP, Pang XW, et al. (2003). "HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma.". Lab. Invest. 83 (8): 1185–92. doi:10.1097/01.LAB.0000080605.73839.96. PMID 12920247.
• Ma W, Germeau C, Vigneron N, et al. (2004). "Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2.". Int. J. Cancer 109 (5): 698–702. doi:10.1002/ijc.20038. PMID 14999777.
• Wang Y, Liang Z, Yuan YH, et al. (2004). "[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]". Zhonghua Yi Xue Za Zhi 84 (6): 464–8. PMID 15061963.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Godelaine D, Carrasco J, Brasseur F, et al. (2007). "A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44.". Cancer Immunol. Immunother. 56 (6): 753–9. doi:10.1007/s00262-006-0244-5. PMID 17096150.
• Yang B, Wu J, Maddodi N, et al. (2007). "Epigenetic control of MAGE gene expression by the KIT tyrosine kinase.". J. Invest. Dermatol. 127 (9): 2123–8. doi:10.1038/sj.jid.5700836. PMID 17495964.