MAML1

Mastermind-like transcriptional coactivator 1
PDB rendering based on 2f8x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F8X​, 3NBN​, 3V79​
Identifiers
Symbols	MAML1 ; Mam-1; Mam1
External IDs	OMIM: 605424 MGI: 1890504 HomoloGene: 8845 GeneCards: MAML1 Gene
Gene ontology Molecular function • transcription coactivator activity • protein binding • protein kinase binding • peptide antigen binding Cellular component • MAML1-RBP-Jkappa- ICN1 complex • nucleus • nucleoplasm • nuclear speck • intracellular membrane-bounded organelle Biological process • atrioventricular node development • transcription initiation from RNA polymerase II promoter • protein phosphorylation • Notch signaling pathway • positive regulation of transcription of Notch receptor target • gene expression • positive regulation of myotube differentiation • myoblast differentiation • positive regulation of transcription from RNA polymerase II promoter • atrioventricular node cell development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9794	103806
Ensembl	ENSG00000161021	ENSMUSG00000050567
UniProt	Q92585	Q6T264
RefSeq (mRNA)	NM_014757	NM_175334
RefSeq (protein)	NP_055572	NP_780543
Location (UCSC)	Chr 5: 179.73 – 179.8 Mb	Chr 11: 50.26 – 50.29 Mb
PubMed search

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.^[1][2][3]

Function

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.^[3]

Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.

Interactions

MAML1 has been shown to interact with EP300^[4][5] and NOTCH1.^[1][6]

References

1. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet 26 (4): 484–9. doi:10.1038/82644. PMID 11101851.
2. Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC 87094. PMID 11390662.
3. "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)".
4. Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
5. Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
6. Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.

Further reading

• Alves-Guerra MC, Ronchini C, Capobianco AJ (2007). "Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.". Cancer Res. 67 (18): 8690–8. doi:10.1158/0008-5472.CAN-07-1720. PMID 17875709.
• Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V (2007). "The notch regulator MAML1 interacts with p53 and functions as a coactivator.". J. Biol. Chem. 282 (16): 11969–81. doi:10.1074/jbc.M608974200. PMID 17317671.
• Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006). "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.". Cell 124 (5): 973–83. doi:10.1016/j.cell.2005.12.037. PMID 16530044.
• Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.". Mol. Cell 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.
• Nam Y, Weng AP, Aster JC, Blacklow SC (2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.". J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
• Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
• Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling.". J. Biol. Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
• Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
• Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMC 99913. PMID 11585921.