MAP1A

Microtubule-associated protein 1A
Identifiers
Symbols MAP1A ; MAP1L; MTAP1A
External IDs OMIM: 600178 HomoloGene: 1778 GeneCards: MAP1A Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4130 17754
Ensembl ENSG00000166963 ENSMUSG00000027254
UniProt P78559 Q9QYR6
RefSeq (mRNA) NM_002373 NM_001173506
RefSeq (protein) NP_002364 NP_001166977
Location (UCSC) Chr 15:
43.51 – 43.53 Mb
Chr 2:
121.29 – 121.31 Mb
PubMed search

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.[1][2][3]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.[3]

Interactions

MAP1A has been shown to interact with DISC1.[4]

References

  1. Lien LL, Feener CA, Fischbach N, Kunkel LM (Jan 1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212. Check date values in: |year= / |date= mismatch (help)
  2. Fukuyama R, Rapoport SI (Sep 1995). "Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15". J. Neurosci. Res. 40 (6): 820–5. doi:10.1002/jnr.490400613. PMID 7629894.
  3. 1 2 "Entrez Gene: MAP1A microtubule-associated protein 1A".
  4. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.

Further reading


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