MAPRE3

Microtubule-associated protein, RP/EB family, member 3
PDB rendering based on 1wyo.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WYO​, 3CO1​, 3TQ7​
Identifiers
Symbols	MAPRE3 ; EB3; EBF3; EBF3-S; RP3
External IDs	OMIM: 605788 MGI: 2140967 HomoloGene: 56565 GeneCards: MAPRE3 Gene
Gene ontology Molecular function • protein binding • microtubule binding Cellular component • cytoplasm • cytoplasmic microtubule • microtubule cytoskeleton • midbody • microtubule plus-end • perinuclear region of cytoplasm Biological process • mitotic nuclear division • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of transcription, DNA-templated • cell division • positive regulation of microtubule plus-end binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22924	100732
Ensembl	ENSG00000084764	ENSMUSG00000029166
UniProt	Q9UPY8	Q6PER3
RefSeq (mRNA)	NM_001303050	NM_133350
RefSeq (protein)	NP_001289979	NP_579928
Location (UCSC)	Chr 2: 26.97 – 27.03 Mb	Chr 5: 30.81 – 30.87 Mb
PubMed search

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.^[1][2]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.^[2]

References

1. Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol 159 (3): 1276–83. PMID 9233623.
2. "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

Further reading

• Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer 81 (2): 275–84. doi:10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z. PMID 10188731.
• Nakagawa H, Koyama K, Murata Y, et al. (2000). "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue". Oncogene 19 (2): 210–6. doi:10.1038/sj.onc.1203308. PMID 10644998.
• Su LK, Qi Y (2001). "Characterization of human MAPRE genes and their proteins". Genomics 71 (2): 142–9. doi:10.1006/geno.2000.6428. PMID 11161807.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
• Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
• Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell. Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.