MARCH2

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Identifiers
Symbols	MARCH2 ; HSPC240; MARCH-II; RNF172
External IDs	OMIM: 613332 MGI: 1925915 HomoloGene: 9539 GeneCards: MARCH2 Gene
EC number	6.3.2.-
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity Cellular component • lysosomal membrane • endoplasmic reticulum • endoplasmic reticulum membrane • endosome membrane • integral component of membrane • cytoplasmic vesicle Biological process • endocytosis • protein ubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51257	224703
Ensembl	ENSG00000099785	ENSMUSG00000079557
UniProt	Q9P0N8	Q99M02
RefSeq (mRNA)	NM_001005415	NM_001252480
RefSeq (protein)	NP_001005415	NP_001239409
Location (UCSC)	Chr 19: 8.41 – 8.44 Mb	Chr 17: 33.69 – 33.72 Mb
PubMed search

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene.^[1][2][3]

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
3. "Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nakamura N, Fukuda H, Kato A, Hirose S (2005). "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.". Mol. Biol. Cell 16 (4): 1696–710. doi:10.1091/mbc.E04-03-0216. PMC 1073653. PMID 15689499.
• Fukuda H, Nakamura N, Hirose S (2007). "MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II.". J. Biochem. 139 (1): 137–45. doi:10.1093/jb/mvj012. PMID 16428329.