MCC (gene)
| Mutated in colorectal cancers | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MCC ; MCC1 | ||||||||||||
| External IDs | OMIM: 159350 HomoloGene: 20539 GeneCards: MCC Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4163 | 328949 | |||||||||||
| Ensembl | ENSG00000171444 | ENSMUSG00000071856 | |||||||||||
| UniProt | P23508 | E9PWI3 | |||||||||||
| RefSeq (mRNA) | NM_001085377 | NM_001033406 | |||||||||||
| RefSeq (protein) | NP_001078846 | NP_001078842 | |||||||||||
| Location (UCSC) |
Chr 5: 113.02 – 113.49 Mb |
Chr 18: 44.43 – 44.81 Mb | |||||||||||
| PubMed search | |||||||||||||
Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[1][2]
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A; et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370.
- 1 2 "Entrez Gene: MCC mutated in colorectal cancers".
Further reading
- Lindgren V, Bryke CR, Ozcelik T, et al. (1992). "Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis". Am. J. Hum. Genet. 50 (5): 988–97. PMC 1682619. PMID 1315124.
- Nishisho I, Nakamura Y, Miyoshi Y, et al. (1991). "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients". Science 253 (5020): 665–9. doi:10.1126/science.1651563. PMID 1651563.
- Hoshino Y, Horikawa I, Oshimura M, Yuasa Y (1991). "Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity". Biochem. Biophys. Res. Commun. 174 (1): 298–304. doi:10.1016/0006-291X(91)90520-H. PMID 1846539.
- Curtis LJ, Bubb VJ, Gledhill S, et al. (1994). "Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer". Hum. Mol. Genet. 3 (3): 443–6. doi:10.1093/hmg/3.3.443. PMID 8012355.
- Matsumine A, Senda T, Baeg GH, et al. (1996). "MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase". J. Biol. Chem. 271 (17): 10341–6. doi:10.1074/jbc.271.17.10341. PMID 8626604.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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