MDH1

malate dehydrogenase 1, NAD (soluble)
Identifiers
Aliases MDH1, HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2
External IDs MGI: 97051 HomoloGene: 4324 GeneCards: 4190
EC number 1.1.1.96
Orthologs
Species Human Mouse
Entrez

4190

17449

Ensembl

ENSG00000014641

ENSMUSG00000020321

UniProt

P40925

P14152

RefSeq (mRNA)

NM_005917
NM_001199111
NM_001199112
NM_001316374

NM_008618
NM_001316675

RefSeq (protein)

NP_001186040.1
NP_001186041.1
NP_005908.1
NP_001303303.1

NP_001303604.1
NP_032644.3

Location (UCSC) Chr 2: 63.59 – 63.61 Mb Chr 11: 21.56 – 21.57 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.[1]

Function

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article

|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

  1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the Saturday, April 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.