MED25

Mediator complex subunit 25
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KY6​, 2L23​, 2L6U​, 2XNF​
Identifiers
Symbols	MED25 ; ACID1; ARC92; BVSYS; CMT2B2; P78; PTOV2; TCBAP0758
External IDs	OMIM: 610197 MGI: 1922863 HomoloGene: 12614 GeneCards: MED25 Gene
Gene ontology Molecular function • protein binding • transcription factor binding • retinoic acid receptor binding • retinoid X receptor binding Cellular component • nucleoplasm • nuclear transcription factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • gene expression • positive regulation of chromatin binding • positive regulation of transcription from RNA polymerase II promoter • negative regulation of fibroblast proliferation • positive regulation of cell cycle arrest • positive regulation of mediator complex assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81857	75613
Ensembl	ENSG00000104973	ENSMUSG00000002968
UniProt	Q71SY5	Q8VCB2
RefSeq (mRNA)	NM_030973	NM_029365
RefSeq (protein)	NP_112235	NP_083641
Location (UCSC)	Chr 19: 49.82 – 49.84 Mb	Chr 7: 44.88 – 44.89 Mb
PubMed search

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.^[1][2][3]

Interactions

MED25 has been shown to interact with MED4.^[4]

References

1. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
3. "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)".
4. Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.

Further reading

• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (Aug 2002). "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein". Biochemical and Biophysical Research Communications 296 (2): 281–7. doi:10.1016/S0006-291X(02)00872-0. PMID 12163014.
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M (Dec 2003). "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". The EMBO Journal 22 (24): 6494–504. doi:10.1093/emboj/cdg619. PMC 291814. PMID 14657022.
• Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America 101 (8): 2339–44. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
• Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
• Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG (Jul 2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell 19 (1): 89–100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
• Lee HK, Park UH, Kim EJ, Um SJ (Aug 2007). "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation". The EMBO Journal 26 (15): 3545–57. doi:10.1038/sj.emboj.7601797. PMC 1949011. PMID 17641689.

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2