MEGF10

Multiple EGF-like-domains 10
Identifiers
Symbols	MEGF10 ; EMARDD
External IDs	OMIM: 612453 HomoloGene: 23771 GeneCards: MEGF10 Gene
Gene ontology Cellular component • phagocytic cup • integral component of membrane • basolateral plasma membrane • cell projection Biological process • skeletal muscle satellite cell activation • skeletal muscle satellite cell differentiation • skeletal muscle satellite cell proliferation • homotypic cell-cell adhesion • recognition of apoptotic cell • regulation of skeletal muscle tissue development • regulation of muscle cell differentiation • muscle cell development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84466	70417
Ensembl	ENSG00000145794	ENSMUSG00000024593
UniProt	Q96KG7	Q6DIB5
RefSeq (mRNA)	NM_001256545	NM_001001979
RefSeq (protein)	NP_001243474	NP_001001979
Location (UCSC)	Chr 5: 127.29 – 127.47 Mb	Chr 18: 57.13 – 57.3 Mb
PubMed search

Multiple EGF-like-domains 10 is a protein that in humans is encoded by the MEGF10 gene.^[1]

MEGF10 is a regulator of satellite cell myogenesis. It has been shown to be the cause of early-onset myopathy, areflexia, respiratory distress and dysphagia.^[2]

MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells in mice. These cells are less likely to be near neighbours of the same subtype than would occur by chance, resulting in ‘exclusion zones’ that separate them. Mosaic arrangements provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.^[3]

References

1. "Entrez Gene: Multiple EGF-like-domains 10". Retrieved 2011-11-26.
2. Logan CV, Lucke B, Pottinger C, Abdelhamed ZA, Parry DA, Szymanska K, Diggle CP, Riesen AV, Morgan JE, Markham G, Ellis I, Manzur AY, Markham AF, Shires M, Helliwell T, Scoto M, Hübner C, Bonthron DT, Taylor GR, Sheridan E, Muntoni F, Carr IM, Schuelke M, Johnson CA (November 2011). "Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)". Nat Genet 43 (12): 1189–92. doi:10.1038/ng.995. PMID 22101682.
3. Kay, Jeremy N.; Chu, Monica W.; Sanes, Joshua R. (March 2012). "MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons". Nature 483: 465–9. doi:10.1038/nature10877. PMID 22407321.

Further reading

• Hamon, Y.; Trompier, D.; Ma, Z.; Venegas, V.; Pophillat, M.; Mignotte, V.; Zhou, Z.; Chimini, G. (2006). Insall, Robert, ed. "Cooperation between Engulfment Receptors: The Case of ABCA1 and MEGF10". PLoS ONE 1 (1): e120. doi:10.1371/journal.pone.0000120. PMC 1762421. PMID 17205124.
• Suzuki, E.; Nakayama, M. (2007). "The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern". Experimental Cell Research 313 (11): 2451–2464. doi:10.1016/j.yexcr.2007.03.041. PMID 17498693.
• Suzuki, E.; Nakayama, M. (2007). "MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation". Experimental Cell Research 313 (17): 3729–3742. doi:10.1016/j.yexcr.2007.06.015. PMID 17643423.
• Chen, X.; Wang, X.; Chen, Q.; Williamson, V.; Van Den Oord, E.; Maher, B. S.; O'Neill, F. A.; Walsh, D.; Kendler, K. S. (2008). "MEGF10 Association with Schizophrenia". Biological Psychiatry 63 (5): 441–448. doi:10.1016/j.biopsych.2007.11.003. PMC 2268016. PMID 18179784.
• Kang, S.; Zhao, J.; Liu, Q.; Zhou, R.; Wang, N.; Li, Y. (2009). "Vascular endothelial growth factor gene polymorphisms are associated with the risk of developing adenomyosis". Environmental and Molecular Mutagenesis 50 (5): 361–366. doi:10.1002/em.20455. PMID 19197986.
• Chen, X.; Sun, C.; Chen, Q.; O'Neill, F. A.; Walsh, D.; Fanous, A. H.; Chowdari, K. V.; Nimgaonkar, V. L.; Scott, A.; Schwab, S. G.; Wildenauer, D. B.; Che, R.; Tang, W.; Shi, Y.; He, L.; Luo, X. J.; Su, B.; Edwards, T. L.; Zhao, Z.; Kendler, K. S. (2009). Okazawa, Hitoshi, ed. "Apoptotic Engulfment Pathway and Schizophrenia". PLoS ONE 4 (9): e6875. doi:10.1371/journal.pone.0006875. PMC 2731162. PMID 19721717.
• Yun, L.; Gu, Y.; Hou, Y. (2011). "No association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case–control sample". Psychiatry Research 186 (2–3): 467–468. doi:10.1016/j.psychres.2010.08.002. PMID 20813413.
• Singh, T. D.; Park, S. Y.; Bae, J. S.; Yun, Y.; Bae, Y. C.; Park, R. W.; Kim, I. S. (2010). "MEGF10 functions as a receptor for the uptake of amyloid-β". FEBS Letters 584 (18): 3936–3942. doi:10.1016/j.febslet.2010.08.050. PMID 20828568.

External links

• NCBI gene