MEOX1

Mesenchyme homeobox 1
Identifiers
Symbols	MEOX1 ; KFS2; MOX1
External IDs	OMIM: 600147 MGI: 103220 HomoloGene: 3326 GeneCards: MEOX1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • molecular_function • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding • HMG box domain binding Cellular component • nucleus • cytoplasm Biological process • somite specification • transcription from RNA polymerase II promoter • multicellular organismal development • biological_process • positive regulation of transcription from RNA polymerase II promoter • hematopoietic stem cell differentiation • somite development • sclerotome development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4222	17285
Ensembl	ENSG00000005102	ENSMUSG00000001493
UniProt	P50221	P32442
RefSeq (mRNA)	NM_001040002	NM_010791
RefSeq (protein)	NP_001035091	NP_034921
Location (UCSC)	Chr 17: 43.64 – 43.66 Mb	Chr 11: 101.88 – 101.89 Mb
PubMed search

Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.^[1][2]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.^[2]

Interactions

MEOX1 has been shown to interact with PAX1^[3] and PAX3.^[3]

References

1. Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.
2. "Entrez Gene: MEOX1 mesenchyme homeobox 1".
3. Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.

Further reading

• Jones KA, Black DM, Brown MA, Griffiths BL, Nicolai HM, Chambers JA, Bonjardim M, Xu CF, Boyd M, McFarlane R (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase". Hum. Mol. Genet. 3 (11): 1927–34. doi:10.1093/hmg/3.11.1927. PMID 7874108.
• Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin". Differentiation 62 (1): 33–41. doi:10.1046/j.1432-0436.1997.6210033.x. PMID 9373945.
• Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.
• Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells". J. Biol. Chem. 279 (23): 23874–81. doi:10.1074/jbc.M312612200. PMID 15039437.
• Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells". J. Biol. Chem. 280 (22): 21022–8. doi:10.1074/jbc.M502977200. PMID 15793308.
• Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.