MFN1
| Mitofusin 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MFN1 ; hfzo1; hfzo2 | ||||||||||||
| External IDs | OMIM: 608506 MGI: 1914664 HomoloGene: 11481 GeneCards: MFN1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55669 | 67414 | |||||||||||
| Ensembl | ENSG00000171109 | ENSMUSG00000027668 | |||||||||||
| UniProt | Q8IWA4 | Q811U4 | |||||||||||
| RefSeq (mRNA) | NM_017927 | NM_024200 | |||||||||||
| RefSeq (protein) | NP_284941 | NP_077162 | |||||||||||
| Location (UCSC) |
Chr 3: 179.35 – 179.39 Mb |
Chr 3: 32.53 – 32.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[1][2][3]
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[3]
References
- ↑ Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.
- ↑ Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci 114 (Pt 5): 867–74. PMID 11181170.
- 1 2 "Entrez Gene: MFN1 mitofusin 1".
Further reading
- Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase". Cell 90 (1): 121–9. doi:10.1016/S0092-8674(00)80319-0. PMID 9230308.
- Chung JG, Yeh KT, Wu SL, et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display". Cancer Res. 61 (24): 8873–9. PMID 11751411.
- Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo". J. Cell. Sci. 115 (Pt 8): 1663–74. PMID 11950885.
- Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins". Mol. Biol. Cell 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMC 138638. PMID 12475957.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Santel A, Frank S, Gaume B, et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells". J. Cell. Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID 12759376.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. doi:10.1073/pnas.0407043101. PMC 528769. PMID 15509649.
- Cartoni R, Léger B, Hock MB, et al. (2005). "Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise". J. Physiol. (Lond.) 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMC 1474174. PMID 15961417.
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