MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Identifiers
Symbol MFNG
External IDs OMIM: 602577 MGI: 1095404 HomoloGene: 1803 GeneCards: MFNG Gene
EC number 2.4.1.222
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4242 17305
Ensembl ENSG00000100060 ENSMUSG00000018169
UniProt O00587 O09008
RefSeq (mRNA) NM_001166343 NM_008595
RefSeq (protein) NP_001159815 NP_032621
Location (UCSC) Chr 22:
37.47 – 37.49 Mb
Chr 15:
78.76 – 78.77 Mb
PubMed search

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene.[1][2][3]

This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.[3]

References

  1. Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
  2. Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development 124 (11): 2245–54. PMID 9187150.
  3. 1 2 "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase".

Further reading

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