MHC

MHC may refer to:

Biology

• Myosin heavy chain - part of the motor protein myosin's quaternary protein structure
• Major histocompatibility complex - a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions

Colleges

• Mars Hill College - a coeducational, liberal-arts college affiliated with the North Carolina Baptist Convention in Mars Hill, North Carolina, USA
• Macaulay Honors College - an honors college within the City University of New York
• Mount Holyoke College - a liberal arts women's college and a member of the Seven Sisters in South Hadley, Massachusetts, USA

Health

• Managed health care
• Mental Health Counselor

Military

• The US Navy hull classification symbol for Coastal Minehunter
• Multiple Hypothesis Correlation

People

• Matthew Henry Commentary (Biblical)
• Mary Higgins Clark, American suspense author

Other

• Manhattan Clique, music producers, remixers and writers
• MHC, a station identifier of the U.S. National Hurricane Center
• Mid Hudson Conference
• The Mile high club
• Milwaukee Hurling Club
• Model of hierarchical complexity
• Mohawk–Hudson convergence, a meteorological phenomenon
• Maimonides Heritage Center
• Malaysian Hockey Confederation