MKL2

MKL/myocardin-like 2
Identifiers
Symbols	MKL2 ; MRTF-B; MRTFB; NPD001
External IDs	OMIM: 609463 MGI: 3050795 HomoloGene: 40917 GeneCards: MKL2 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • actin binding • protein binding Cellular component • nucleus • cytoplasm Biological process • in utero embryonic development • liver development • heart morphogenesis • transcription, DNA-templated • muscle organ development • positive regulation of striated muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • blood vessel morphogenesis • embryonic organ development • cardiac muscle tissue development • smooth muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57496	239719
Ensembl	ENSG00000186260	ENSMUSG00000009569
UniProt	Q9ULH7	P59759
RefSeq (mRNA)	NM_001308142	NM_001122667
RefSeq (protein)	NP_001295071	NP_001116139
Location (UCSC)	Chr 16: 14.07 – 14.27 Mb	Chr 16: 13.26 – 13.42 Mb
PubMed search

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.^[1][2]

References

1. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
2. "Entrez Gene: MKL2 MKL/myocardin-like 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.". Mol. Cell. Biol. 23 (18): 6597–608. doi:10.1128/MCB.23.18.6597-6608.2003. PMC 193697. PMID 12944485.
• Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.". J. Biol. Chem. 278 (43): 41977–87. doi:10.1074/jbc.M305679200. PMID 14565952.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.". J. Cell Biol. 179 (5): 1027–42. doi:10.1083/jcb.200708174. PMC 2099179. PMID 18056415.