MLST8

MTOR associated protein, LST8 homolog
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 4JT6
Identifiers
Symbols	MLST8 ; GBL; GbetaL; LST8; POP3; WAT1
External IDs	OMIM: 612190 MGI: 1929514 HomoloGene: 6833 GeneCards: MLST8 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleoplasm • cytoplasm • cytosol Biological process • transcription initiation from RNA polymerase II promoter • cell cycle arrest • epidermal growth factor receptor signaling pathway • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • gene expression • positive regulation of actin filament polymerization • T cell costimulation • positive regulation of TOR signaling • regulation of actin cytoskeleton organization • cellular response to heat • Fc-epsilon receptor signaling pathway • regulation of GTPase activity • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of peptidyl-tyrosine phosphorylation • regulation of cellular response to heat Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64223	56716
Ensembl	ENSG00000167965	ENSMUSG00000024142
UniProt	Q9BVC4	Q9DCJ1
RefSeq (mRNA)	NM_001199173	NM_001252463
RefSeq (protein)	NP_001186102	NP_001239392
Location (UCSC)	Chr 16: 2.2 – 2.21 Mb	Chr 17: 24.47 – 24.48 Mb
PubMed search

Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.^[1]

References

1. "Entrez Gene: MTOR associated protein".

Further reading

• Ali SM, Sabatini DM (2005). "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.". J. Biol. Chem. 280 (20): 19445–8. doi:10.1074/jbc.C500125200. PMID 15809305.
• Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (2001). "Insulin regulation of a novel WD-40 repeat protein in adipocytes.". J. Endocrinol. 168 (2): 325–32. doi:10.1677/joe.0.1680325. PMID 11182770.
• Long X, Lin Y, Ortiz-Vega S, et al. (2005). "Rheb binds and regulates the mTOR kinase.". Curr. Biol. 15 (8): 702–13. doi:10.1016/j.cub.2005.02.053. PMID 15854902.
• Kaizuka T, Hara T, Oshiro N, et al. (2010). "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.". J. Biol. Chem. 285 (26): 20109–16. doi:10.1074/jbc.M110.121699. PMC 2888423. PMID 20427287.
• Loewith R, Jacinto E, Wullschleger S, et al. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.". Mol. Cell 10 (3): 457–68. doi:10.1016/S1097-2765(02)00636-6. PMID 12408816.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Sarbassov DD, Sabatini DM (2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.". J. Biol. Chem. 280 (47): 39505–9. doi:10.1074/jbc.M506096200. PMID 16183647.
• Oshiro N, Yoshino K, Hidayat S, et al. (2004). "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.". Genes Cells 9 (4): 359–66. doi:10.1111/j.1356-9597.2004.00727.x. PMID 15066126.
• Inoki K, Ouyang H, Li Y, Guan KL (2005). "Signaling by target of rapamycin proteins in cell growth control.". Microbiol. Mol. Biol. Rev. 69 (1): 79–100. doi:10.1128/MMBR.69.1.79-100.2005. PMC 1082789. PMID 15755954.
• Behrends C, Sowa ME, Gygi SP, Harper JW (2010). "Network organization of the human autophagy system.". Nature 466 (7302): 68–76. doi:10.1038/nature09204. PMC 2901998. PMID 20562859.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kawai S, Enzan H, Hayashi Y, et al. (2003). "Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.". Virchows Arch. 443 (1): 78–86. doi:10.1007/s00428-003-0804-4. PMID 12719976.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim DH, Sarbassov DD, Ali SM, et al. (2003). "GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.". Mol. Cell 11 (4): 895–904. doi:10.1016/S1097-2765(03)00114-X. PMID 12718876.
• Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.". Nat. Cell Biol. 6 (11): 1122–8. doi:10.1038/ncb1183. PMID 15467718.
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.". Science 307 (5712): 1098–101. doi:10.1126/science.1106148. PMID 15718470.